Drug Interaction Between Paracetamol and Warfarin "INPAWA2"


Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria

- Patients treated with warfarin (target INR 2 to 3) stable anticoagulation at 2 to 9 mg for more than 30 days
- Aged 18 years or older
- Laboratory values (hemoglobin, blood cell counts, albumin, blood ionogram, complementary hemostasis parameters and aspartate, alanine transaminases (AST and ALT))remained within normal limits

Exclusion Criteria

- Any treatment change within 7 days before enrollment
- Any paracetamol intake within the last 14 days
- Drug allergy Concomitant drug ( 5-fluorouracile, acetylsalicylic acid, non steroidal anti-inflammatory drugs, chloramphenicol, diflunisal, miconazole)
- St John's wort treatment
- Pregnancy