To determine the feasibility and safety of using drug-eluting stents (DES) for patients with symptomatic intracranial atherosclerosis.
- Aspirin (stroke prevention) Drug
Intervention Desc: Antiplatelet agent; inhibits thromboxane A2
- Clopidogrel (Plavix®)Drug
Other Names: Plavix Intervention Desc: Antiplatelet agent
- Stent, carotid Procedure/Surgery
Intervention Desc: Intravascular procedure to maintain carotid artery patency
Prospective, clinical trial.
All of the patients were pretreated with 325 mg of aspirin and 75 mg of clopidogrel for >/=4 days before intervention, and all were given unfractionated heparin intraprocedurally and stopped postprocedurally. All patients were underwent thorough cerebral angiography, under local anesthesia, with brief neurological assessments performed throughout. Patients were discharged to home the following day on a regimen of 325 mg of aspirin lifelong and 75 mg of clopidogrel daily for 1 year.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Amount of reduction in stenosis severity to </=50% luminal narrowing without angiographic evidence of distal embolization, flow-limiting dissection, or contrast extrava-sation. Angiographic restenosis was defined as >/=50% stenosis within the stent or just outside the stent margins.|