Dopaminergic Enhancement of Learning and Memory in Aphasia


Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria for patients with aphasia:
- Unilateral cerebrovascular accident (stroke) in the territory of the arteria media
- Time post onset: > 6 months
- Aphasia with anomia
- Age between 18-75 years
- Premorbid right-handedness
- Primary language: German
Exclusion Criteria for patients and healthy controls:
- Known allergy to levodopa or tartrazine
- History of medication/drug abuse
- Acute nicotine withdrawal or > 15 cigarettes per day
- > 6 cups/glasses of coffee, caffeine drinks or energy drinks per day
- > 50 grams of alcohol per day
- Severe hypertonia (systole >180 mm Hg)
- Severe arteriosclerosis
- Diabetes, asthma, or glaucoma
- Severe hearing disability
- Evidence for severe hippocampal damage
- Premorbid depression or psychosis
- Medication with dopamine agonists or antagonists
- Parkinsonian symptoms
- Changes in anticonvulsive medication during the week prior to study enrollment