Dopaminergic Enhancement of Learning and Memory in Aphasia


Phase 4 Results N/A

Trial Description

The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.

Detailed Description

Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether daily administration of levodopa, coupled with several hours of language training every day, will significantly improve naming abilities in patients with aphasia as compared to placebo administration. We furthermore examine with magnetic resonance imaging which brain regions need to be functionally intact for a dopaminergic improvement of language therapy.



  • Levodopa Drug
    Intervention Desc: 100mg levodopa per day over 10 days/ treatment phase

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Crossover Assignment


Type Measure Time Frame Safety Issue
Primary Boost in naming performance (percent correct) through levodopa as compared to placebo
Primary Brain activity pattern in successfully trained patients
Secondary Stability of naming performance after one month and six months post treatment