Diurnal Variation in Hypertensive Stroke Patients

Completed

Phase 4 Results N/A

Trial Description

This study was conducted to evaluate and compare the effectiveness of Amodipin® (amlodipine camsylate) with that of Cozaar® (losartan potassium) in hypertensive patients with an acute ischemic stroke by measuring their 24-hour ambulatory BP (ABP).

Conditions

Interventions

  • Amlodipine, Losartan Drug
    ARM 1: Kind: Experimental
    Label: amlodipine camsylate
    Description: amlodipine camsylate 5mg
    ARM 2: Kind: Experimental
    Label: losartan potassium
    Description: losartan potassium 50mg

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary 24-hour ambulatory mean SBP baseline and 8weeks No
Secondary 24H mean DBP, 24H mean SBP/DBP Variability,clinic SBP/DBP, awake, sleep, morning, evening, and prewake BPs, the morning surge, and the nocturnal dipping baseline and 8weeks No

Sponsors