Diffusion-weighted Imaging Evaluation For Understanding Stroke Evolution "DEFUSE"

Recruiting

Phase N/A Results

Trial Description

To investigate whether specific profiles on DWI and PWI predict a favorable clinical response to intravenous t-PA therapy administered between 3 and 6 hours after stroke onset.

Interventions

Trial Design

Open label, multi-center, pilot study.

Patient Involvement

Patient needs baseline MR or CT prior to start of tPA. Second MRI 3 to 6 hours after initial bolus of tPA.

Outcomes

Type Measure Time Frame Safety Issue
No outcomes associated with this trial.

Sponsors

NIH