This phase 1 study tests whether use of the Modified Atkins Diet (MAD) can improve motor impairment after stroke. It is based on the hypothesis that after stroke, the brain's utilization of glucose, it's primary source of energy, is disrupted. The MAD is a low-carbohydrate diet that has can switch the body's metabolism from using glucose to using products of fat metabolism, so-called ketones. Ketones may act as an alternative energy substrate for the brain. Ketones also have several neuroprotective effects after stroke.
- Modified Atkins diet Other
Intervention Desc: A high fat, high protein, low- carbohydrate diet ARM 1: Kind: Experimental Label: Modified Atkins Diet Description: Patients will receive a 14 day menu consisting of the Modified Atkins diet, a low-carbohydrate, high protein, high fat diet.
- Control diet Other
Other Names: Low sodium diet; low sodium/ low cholesterol diet; regular diet; diabetic diet Intervention Desc: The control diet is a diet determined by the attending physician caring for the patient and may consist of either a low sodium diet, a low sodium/ low cholesterol diet, a regular diet or a diabetic diet. ARM 1: Kind: Experimental Label: Control Diet Description: Patients will receive a diet (e.g. regular, low cholesterol, diabetic) determined by the attending physician.
- Allocation: Randomized
- Masking: Single Blind (Outcomes Assessor)
- Purpose: Treatment
- Endpoint: Safety/Efficacy Study
- Intervention: Parallel Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||Change in Upper Extremity Fugl Meyer Motor Score||assessed upon beginning of the study, discharge from Burke Rehabilitation Hospital (average 25 days post study enrollment) and at 3 months post discharge||No|
|Secondary||Change in Montreal Cognitive Assessment (MOCA)||assessed upon beginning of the study, discharge from Burke Rehabilitation Hospital (average 25 days post study enrollment) and at 3 months post discharge||No|