Dextroamphetamine and tDCS to Improve the Fluency


Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- Age above 18
- Native English proficiency;
- Nonfluent speech;
- Premorbid right handedness;
- Non-hemorrhagic left hemispheric stroke at least 6 months prior to the investigation.
- No contraindications for MRI (only subjects who will undergo MRI scan).

Exclusion Criteria

- Hypersensitivity or idiosyncrasy to dextroamphetamine or to other sympathomimetic agents;
- Pregnant or trying to become pregnant;
- Active alcohol abuse, illicit drug use or drug abuse or significant mental illness;
- Subjects receiving alpha adrenergic antagonists or agonists;
- Any history of epilepsy;
- Any condition that would prevent the subject from giving voluntary informed consent;
- An implanted brain stimulator;
- Aneurysm clip or other metal in the brain;
- Enrolled or plans to enroll in an interventional trial during this study;
- Scalp wounds or infections;
- Previous stroke with residual deficits (TIAs not a reason for exclusion);
- A concurrent progressive neurologic disorder, acute coronary syndrome, severe heart disease (NYHA Classification > 3), or other major medical condition;
- Advanced atherosclerosis, Unstable cardiac dysrhythmia or uncontrolled hypertension (>160/100 mm Hg), or untreated hyperthyroidism;
- Diagnosis of glaucoma
- During or within 14 days following the administration of monoamine oxidase inhibitors;
- Subjects requiring palliative care;
- Terminal medical condition such as AIDS or cancer;
- Subjects unable to comprehend or follow verbal commands;
- Based on PI's or local physician's assessment patient unable to tolerate the trial procedure due to medical condition;