Description and Modeling of Swallowing Disorders After a Stroke "AVC-MODE"

Recruiting

Phase N/A Results N/A

Trial Description

The oropharyngeal junction participates in 3 interpenetrating functions: Swallowing, Breathing and Speech. In the context of ischemic or hemorrhagic stroke, these are altered, isolated or associated manner, causing major disorders and representing a source of handicap for patients.
Understanding the swallowing mechanisms is therefore a major challenge to guide the rehabilitation and improve the initial and long-term prognosis of patients with stroke.
The main objective of this study is to describe and modeling, thanks to a clinical, physiological and radiological knowledge base, swallowing, speech and breathing, in patients with stroke and in healthy subjects.

Conditions

Interventions

  • Neurological evaluation Other
    ARM 1: Kind: Experimental
    Label: Stroke population
    Description: Patient with stroke will be explored during their acute phase and in 6 months of diagnosis.
  • Laryngological evaluation Other
    ARM 1: Kind: Experimental
    Label: Stroke population
    Description: Patient with stroke will be explored during their acute phase and in 6 months of diagnosis.
  • MRI evaluation Other
    ARM 1: Kind: Experimental
    Label: Stroke population
    Description: Patient with stroke will be explored during their acute phase and in 6 months of diagnosis.
  • Breathing investigation Other
    ARM 1: Kind: Experimental
    Label: Stroke population
    Description: Patient with stroke will be explored during their acute phase and in 6 months of diagnosis.
    ARM 2: Kind: Experimental
    Label: Healthy population
    Description: Healthy subjects will be explored in Grenoble in research laboratory
  • MRI and articulatory investigation Other
    ARM 1: Kind: Experimental
    Label: Healthy population
    Description: Healthy subjects will be explored in Grenoble in research laboratory
  • Postural investigation Other
    ARM 1: Kind: Experimental
    Label: Stroke population
    Description: Patient with stroke will be explored during their acute phase and in 6 months of diagnosis.
    ARM 2: Kind: Experimental
    Label: Healthy population
    Description: Healthy subjects will be explored in Grenoble in research laboratory
  • Voice and soundscape investigation Other
    ARM 1: Kind: Experimental
    Label: Stroke population
    Description: Patient with stroke will be explored during their acute phase and in 6 months of diagnosis.
    ARM 2: Kind: Experimental
    Label: Healthy population
    Description: Healthy subjects will be explored in Grenoble in research laboratory

Trial Population

Multicenter study with two cohorts unpaired : first of healthy subjects / second of patient with ischemic stroke. Study size expected : - 120 stroke patients in 4 University Hospital - 30 healthy subjects explored in research laboratory

Outcomes

Type Measure Time Frame Safety Issue
Primary Change of Clinical severity score At inclusion and 6 months after diagnosis
Primary Change of swallowing disorder Within 15 days after diagnosis and 6 months after diagnosis
Secondary Change of aphasia disorder Within 15 days after diagnosis and 6 months after diagnosis
Secondary Change of state of depression and anxiety Within 15 days after diagnosis and 6 months after diagnosis
Secondary Change of behavioural attention Within 15 days after diagnosis and 6 months after diagnosis

Sponsors