To evaluate the effect of very-low-dose aspirin as an antithrombotic agent in patients who had recently undergone carotid endarterectomy.
- Aspirin (stroke prevention) Drug
Intervention Desc: Antiplatelet agent; inhibits thromboxane A2
Randomized, double-blind trial of 301 patients at 2 centers.
Patients were randomized to receive 50 mg of aspirin initially or placebo. If platelet inhibition was <80% compared to baseline after 2 months, it was measured again 1 week later and the aspirin dose was increased in 10-mg increments until satisfactory inhibition had been obtained. Some patients in the placebo group also had their doses adjusted at random with placebo tablets. Interviews and neurologic examinations were performed before and after surgery, 2 months after entry and every 6 months thereafter for an average of about 2 years.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Platelet aggregation, amaurosis fugax, retinal infarction, transient ischemic attack, stroke, acute myocardial infarction, nonvascular death, vascular death.|