Customized Cortical Stimulation Therapy in the Rehabilitation of Stroke Patients


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- The ability to provide informed consent
- Ages 50 to 80 years old
- Male or female
Stroke Patients
- One cerebral ischemic infarction less than 1 month affecting the primary motor output system of the hand at a cortical (M1) level as defined by magnetic resonance imaging (MRI) of the brain
- Paresis of the hand for more than 3 days after their cerebral infarction
- Extension of the wrist (medical research council scale for assessment of muscle power score of at least 3 and greater than 10 degrees) at the time of the enrollment into the study
Healthy Subjects
- Normal MRI of the brain
- Normal neuropsychological testing
- Normal neurological examination

Exclusion Criteria

Stroke Patients
- Neurological disorders other than stroke
- Aphasia that prevents following instructions or inability to communicate effectively with the study team
- Dementia
- Moderate or severe depression
- Contraindication to transcranial magnetic stimulation (TMS) and/or MRI
- Use of central nervous system (CNS) active drugs that block plasticity
Healthy Subjects
- Neurological Disease
- Psychiatric Disease
- Use of CNS active drugs
- Contraindication to TMS