CT Based Definition of a Tissue Window for Acute Stroke Thrombolysis "CT-DEFINE"

Completed

Phase N/A Results N/A

Trial Description

Aim of this study is to define a CT-based "tissue window" for stroke thrombolysis. Our primary hypothesis is that
1. patients with a "tissue window" (favourable non-contrast CT (NCCT) scan and an intracranial occlusion on CT angiography (CTA) or perfusion-CT-mismatch" (area of reduced cerebral blood flow (CBF) > area of reduced cerebral blood volume (CBV)) represent a significant proportion (> 20%)of acute stroke patients and therefore are an important target group for future interventional studies
2. patients with a "tissue window" suffer an unfavourable outcome (> 50 % mRS =>4 at 3 months)if the occluded artery was not recanalized.

Conditions

Trial Design

  • Observation: Cohort
  • Perspective: Prospective
  • Sampling: Probability Sample

Trial Population

Ischemic stroke patients presenting within 12 hrs from symptom onset

Outcomes

Type Measure Time Frame Safety Issue
Primary modified Rankin Scale scores 0-2 90 days No

Sponsors