- Ancrod (Viprinex®)Drug
Intervention Desc: Fibrinogenolytic agent. Purified fraction of pit viper venom, cleaves fibrinogen.
- Dextran Drug
Intervention Desc: Dextran is used as a volume expander.
Randomized, single-blind study involving 30 patients.
Patients were treated with either low-molecular weight dextran and mannitol alone (group A) or in combination with ancrod (group B).
|Type||Measure||Time Frame||Safety Issue|
|Primary||Hemoglobin/hematocrit and RBC count during active treatment and at 12 months, global coagulation tests, blood viscosity, platelet function. Neurological score given in arbitrary units (AU) was measured before treatment and on days 2, 3, 8, and 15, and after 12 months. Also, survival rate at 12 months.|