Constraint-Induced Movement Therapy in Chronic Stroke Patients


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- age > 18 years and < 80 years
- diagnosis of first ischemic stroke
- stroke onset > 6 months prior to study enrollment
- upper extremity hemiparesis with impairment of hand and/or arm:
- active wrist extension ≥20º
- active metacarpophalangeal- and interphalangeal-joints extension ≥ 10°
- muscle tone assessed by the Modified Ashworth Scale (MAS) ≤ 2
- pain assessed by the Visual Analogue Scale (VAS) <4

Exclusion Criteria

- anyone who does not have adequate understanding of verbal or written information in Italian sufficient to complete any test
- impaired cognitive functioning: score less than 24 on the Mini Mental Status Examination (MMSE)
- contraindications to single-pulse transcranial magnetic stimulation (TMS)(TMS will be used to measure cortical excitability): presence of a history of epilepsy, frequent headaches or neck pain, implantable devices (ventriculoperitoneal shunts, pacemakers, intrathecal pumps, intracranial metal implants)
- neurological or psychiatric pathology
- severe cardio-pulmonary, renal, hepatic diseases
- pregnancy