Constraint-Induced Movement Therapy after Subacute Stroke [SPOTRIAS]

Active, not recruiting

Phase N/A Results

Trial Description

To compare the feasibility, safety, and efficacy of constraint-induced movement therapy (CIMT) in combination with conventional physical and occupational therapy with those of conventional therapy alone in the rehabilitation of subacute stroke patients.

Interventions

  • Constraint-induced therapy Behavioral
    Intervention Desc: Rehabilation approach: increased use of the affected extremity after stroke may promote recovery.

Trial Design

Randomized, controlled study.

Patient Involvement

Eligible patients will be randomized into a CIMT group and a conventional therapy group. All patients will undergo 2 weeks of physical and occupational therapy for training the impaired limb. The CIMT group will also have their intact upper limb in a mitten restraint 12 hours daily, in order to train the impaired limb in tasks pertinent to the activities of daily living (ADL's). Upper limb motor performance will be measured at baseline, at 14 days, and 3 months post-randomization. Patients will receive conventional and functional MRI at baseline, 14 days, and 3 months.

Outcomes

Type Measure Time Frame Safety Issue
Primary Modified Wolf Motor Function Test (WMFT), Motor Activity Log (MAL), Fugl-Meyer (FM) scale, Grooved Pegboard Test (GPT), and Actual Amount of Use Test (AAUT).
Secondary Changes in conventional MRI and in cortical mapping on functional MRI.