The overall goal of the CTP to predict Response to recanalization in Ischemic Stroke Project (CRISP) is to develop a practical tool to identify acute stroke patients who are likely to benefit from endovascular therapy.
The project has two main parts. During the first part, the investigators propose to develop a fully automated system (RAPID) for processing of CT Perfusion (CTP) images that will generate brain maps of the ischemic core and penumbra. There will be no patient enrollment in part one of this project.
During the second part, the investigators aim to demonstrate that physicians in the emergency setting, with the aid of a fully automated CTP analysis program (RAPID), can accurately predict response to recanalization in stroke patients undergoing revascularization. To achieve this aim the investigators will conduct a prospective cohort study of 240 consecutive stroke patients who will undergo a CTP scan prior to endovascular therapy. The study will be conducted at four sites (Stanford University, St Luke's Hospital, University of Pittsburgh Medical Center, and Emory University/Grady Hospital). Patients will have an early follow-up MRI scan within 12+/-6 hours to assess reperfusion and a late follow-up MRI scan at day 5 to determine the final infarct.
- Observation: Cohort
- Perspective: Prospective
- Sampling: Probability Sample
acute ischemic stroke patients
|Type||Measure||Time Frame||Safety Issue|
|Primary||NIHSS Score||30 Day||No|
|Secondary||modified Rankin Score||90 day||No|
- Stanford University Lead
- Saint Luke's Health System
- University of Pittsburgh Medical Center, Pittsburgh, PA
- University of Pittsburgh
- Chatanooga Center for Neurological Research
- Emory University Hospital and Grady Hospital, Atlanta, GA
- Saint Luke's Health System, Kansas City, KA
- University of Miami
- Emory University