To compare intra-arterial thrombolysis (IAT) and intravenous thrombolysis (IVT)in ischemic stroke with hyperdense middle cerebral artery sign (HMCAS) patients.
- Tissue plasminogen activator (Activase®)Drug
Other Names: Alteplase; tPA Intervention Desc: Thrombolytic
- Urokinase (Abbokinase®)Drug
Intervention Desc: Thrombolytic agent
- Mechanical Thrombectomy (Merci Retriever)Device
Other Names: Penumbra system; TREVO; Solitaire Intervention Desc: Extraction of cerebral emboli by using a novel retriever, microcatheter and balloon guide catheter system.
Prospective data collection.
All Bernese patients were treated with IAT using urokinase (500,000 to 1,200,000 IU) and mechanical clot disruption up to 6 hours after symptom onset. All Zurich patients were treated with IVT using rt-PA (0.9 mg/kg body weight) up to 3 hours after symptom onset. Data from the two stroke units were then compared.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Mortality rate and the modified Rankin Scale (mRS), dichotomized at three months into favorable (mRS 0-2) and unfavorable (mRS 3-6).|