Inclusion Criteria- acute venous thromboembolism,
- acute coronary syndrome
- receiving UFH therapy.
Exclusion Criteria- non-willing to participate in the study,
- thrombolytic therapy,
- previous treatment with heparin (UFH) of more than one day before randomization,
- history of heparin-induced thrombocytopenia.
- other conditions considering by study clinians that are not suitable for the trail.