Comparative Study of Arterial Properties After an Ischaemic Stroke or an Acute Coronary Syndrome "AVC/SCA"

Recruiting

Phase 3 Results N/A

Trial Description

A pilot, prospective, comparative study. To include both male and female patients who have presented an ischaemic stroke (full stroke or TIA) or an ACS, 5 to 30 days prior to inclusion.
The proposed study aims to investigate and analyse the differences in functional and structural arterial properties between the patients who presented an ischaemic stroke and those who presented ACS. The hypothesis is that the patients in both groups will present differences partly in terms of their "traditional" cardiovascular risk factors, but also in terms of their arterial properties. All of the confounding factors studied (cardiovascular risk factors, treatments) will be taken into account in order to explain the differences in the arterial properties found between the two groups. Furthermore, the prevalence of signs and symptoms in the two populations will be studied.

Detailed Description

A comparative study of structural and functional arterial properties after an ischaemic stroke or an acute coronary syndrome
Objectives:
Primary:
- To determine whether there is a difference in the biomechanical properties of the carotid arteries, assessed by studying their stiffness, after an acute vascular event, depending on whether the event is an ischaemic stroke (either a full stroke or a transitory ischaemic attack (TIA)) or an acute coronary syndrome (ACS).
Secondary:
- To determine whether there is a difference in aortic stiffness and brachial endothelial function after an acute vascular event, depending on whether the event is an ischaemic stroke (full stroke or TIA) or an ACS.
- To compare the blood pressure (BP) levels and the vascular parameters of the two patient groups (the ischaemic stroke group and the ACS group).
- To determine whether there is a difference between the respiratory parameters recorded during sleep after an acute vascular event, depending on whether the event is an ischaemic stroke (full stroke or TIA) or an ACS.

Conditions

Trial Design

  • Observation: Cohort
  • Perspective: Prospective
  • Sampling: Non-Probability Sample

Trial Population

Patients who presented an acute vascular event :an ischaemic stroke (either a full stroke or a transitory ischaemic attack (TIA)) or an acute coronary syndrome (ACS).

Outcomes

Type Measure Time Frame Safety Issue
Primary biomechanical properties of the carotid arteries 1-6 months No
Secondary aortic stiffness and brachial endothelial function 1-6 months No
Secondary blood pressure (BP) levels and the vascular parameters 1-6 months No
Secondary respiratory parameters recorded during sleep 1-6 months No

Biospecimen Retention:Samples Without DNA - whole blood, serum

Sponsors