Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity

Completed

Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria -
- Spasticity resulting from ABI (stroke, including vascular malformations, traumatic brain injury)
- Ashworth Score (resting) of at least 2 of the primary ankle plantarflexor (gastrocnemius)
- Onset of primary illness at least six months prior to study inclusion
- At least 12 years of age
Exclusion Criteria -
- Hypersensitivity or allergy to botulinum toxin
- History of myasthenia gravis or other neuromuscular disease
- Current use of aminoglycosides
- Botulinum toxin or phenol injection to study limb within six months prior to recruitment
- Current use of other spasmolytic drug, such as diazepam, baclofen, dantrolene, tizanidine
- Presence of contracture or significant muscle atrophy
- Pregnancy