Combining Armodafinil With Neuro-rehabilitation to Improve Neurological Recovery and Reduce Disability Post-Stroke

Completed

Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- First clinical stroke, either cerebral infarction or intracerebral hemorrhage
- Severe hemiparesis as measured by a Fugl-Meyer motor scale score of 0-25
- Screening Motricity Index score of 0-83
- Date of stroke onset between 7 to 21 days prior to study inclusion

Exclusion Criteria

- Age less than 18
- Previous clinical stroke
- Pregnant and/or nursing patients
- Major psychiatric history, including psychosis and history of substance abuse
- Dementia
- Known CNS pathology such as brain tumor
- Significant language dysfunction or severe neglect that hinders comprehension, participation, and barrier to testing
- Seizures
- Left ventricular hypertrophy (LVH)
- Mitral valve prolapse (MVP)
- Severe chronic renal failure or severe hepatic failure
- History or current use of anti-epileptic medications, psychostimulants, or neuroleptics
- Current use of diazepam, phenytoin, propranolol, tricyclic antidepressants, steroidal contraceptives, cyclosporine, or theophylline