Combined Lysis of Thrombus in Brain Ischemia with Transcranial Ultrasound and Systemic TPA [SPOTRIAS] "CLOTBUST Phase II"

Completed

Phase N/A Results

Results

Complete recanalization or dramatic clinical recovery within two hours of bolus was observed in 31 of 63 patients (49%) in the ultrasound group and 19 of 63 patients (30%) of the control group (p=.03). Favorable outcome at three months was observed in 22 of 53 patients (42%) in the ultrasound group and 14 of 49 patients (29%) of the control group (p=.20). Three subjects in each group experienced a symptomatic intracerebral hemorrhage.