Clopidogrel of loading dosage to treat acute ischaemic stroke in China "CLASS-CHINA"


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

Ischemic stroke within 48 hours with evidence of computerized tomography (CT) or magnetic resonance imaging (MRI); satisfying the criteria of partial anterior circulation infarction of Oxfordshire Community Stroke Project classification, and large artery atherothrombosis of TOAST classification.

Exclusion Criteria

Patients planned for thrombolysis; any of the following: cardiogenic cerebral embolism, lacuna cerebral infarction, total anterior circulation cerebral infarction, posterior circulation cerebral infarction, cerebral infarction of the etiology rather than atherothrombosis and unidentified etiology; history of allergic reaction to clopidogrel; patients regularly taking oral anticoagulants, heparin or LMWH, thienopyridine (clopidogrel or ticlopidine), aspirin >50 mg/d, Aggrenox before the onset or patients who need long-term use of drugs that affect platelet function; history of bleeding disorder; clinically significant or persistent thrombocytopenia or neutropenia; women who are pregnant or breast-feeding; patients with planned surgery within the next 1 month or with a recent operation or trauma history; severe systematic disorders; i.e. heart, lung, liver, kidney diseases, or malignant tumor or severe gastrointestinal disorder affecting the absorption of drug; enrolled in other clinical trials within the past 3 months.