Clopidogrel for Acute Ischaemia of Recent Onset "CAIRO"

Recruiting

Phase 4 Results N/A

Trial Description

Evaluate the role of loading Clopidogrel in acute ischemic stroke in improving neurological outcome of stroke in cases patients will be non-eligible for, or declined, treatment with or intravenous thrombolysis with rTPA, rTPA is not available or thrombectomy.

Conditions

Interventions

  • Clopidogrel (Plavix┬«)Drug
    Other Names: Plavix
    Intervention Desc: there is 2 groups one group will receive 900 mg Clopidogrel and the other will receive 600 mg Clopidogrel
    ARM 1: Kind: Experimental
    Label: 900 mg Clopidogrel
    Description: 67 patients will receive 12 tablets clopidogrel ( each 75 mg) as total 900 mg each patient
    ARM 2: Kind: Experimental
    Label: 600 mg Clopidogrel
    Description: 67 patient will receive 8 tablets clopidogrel (each 75 mg) as total 600 mg each patient and 4 tablets placebo to receive 12 tablets as total
  • Aspirin Drug
    Other Names: Acetylsalicylic Acid
    Intervention Desc: there's another group will receive 400 mg Aspirin
    ARM 1: Kind: Experimental
    Label: 400 mg Aspirin
    Description: 67 patients will receive 4 tablets Aspirin ( each 75 mg) as total 300 mg for each patient and 8 tablets placebo to receive 12 tablets as total

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver)
  • Purpose: Treatment
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary The change of NIH stroke scale score Baseline and up to 1 week No
Primary Neurologic outcome 3 months No
Secondary Bleeding complications of loading clopidogrel 1 week Yes

Sponsors