Clopidogrel and Aspirin versus Aspirin Alone in Stroke Patients "PLUTO"

Completed

Phase N/A Results

Trial Description

To determine whether clopidogrel with aspirin (C+ASA) will produce more potent platelet inhibition than aspirin alone (ASA) in patients after ischemic stroke.

Interventions

Trial Design

Randomized, controlled, antiplatelet trial.

Patient Involvement

All patients were treated with 81 mg aspirin for at least 1 month before enrollment and were randomly assigned to one of the two groups: C+ASA (75 mg clopidogrel + 81 mg aspirin) or ASA (81 mg.). Patients received platelet tests at baseline and after 30 days after randomization.

Outcomes

Type Measure Time Frame Safety Issue
Primary Platelet tests given to all patients at baseline and after 30 days after randomization.

Sponsors

Sanofi-Aventis/Bristol-Myers Squibb Partnership New York, NY.