Clinical Relevance of Microbleeds In Stroke "CROMIS-2"


Phase N/A Results N/A

Eligibility Criteria

Study I: CROMIS-2 (AF)
Inclusion criteria:
- Adult (≥18y; no upper limit) patients with a clinical diagnosis of non-valvular AF (verified by ECG) with intention to treat with best practice oral anticoagulants (e.g. warfarin)
- Previous ischaemic stroke or TIA diagnosed by treating clinician
- All patients must be able to have GRE MRI before (or within 1 week) of starting best practice oral anticoagulant

Exclusion Criteria

- Any MRI contraindications
- Previous use of oral anticoagulation
- Definite contra-indication to oral anticoagulation
- Serious head injury (resulting to loss of consciousness)
Study II: CROMIS-2 (ICH)
Inclusion criteria:
• Adult (>18y) patients treated at participating centres with confirmed ICH (confirmed on CT or MRI scans) with or without a history of anticoagulant use at the time of the ICH
Exclusion criteria:
- Known underlying structural cause for ICH (e.g arteriovenous malformation, tumour, cavernoma, intracranial aneurysm, haemorrhagic transformation of an infarct)
- Major head trauma (causing loss of consciousness and though to be sufficient to have caused the ICH) in previous 24 hours