Clinical importance of microbleeds in patients receiving IV thrombolysis

Completed

Phase N/A Results

Results

Microbleeds do not appear to increase the risk of hemorrhagic complications in patients with stroke treated with IV tPA. Upon conclusion of the study, it was determined that 15.7% of the patients (11) had microbleeds at baseline GRE, and none of these patients had hemorrhagic complications compared to 10% of the patients (7) with symptomatic hemorrages (5 were major, and 2 were minor) who did not have baseline MBs. Of the 59 patients without MBs, 29 (49.2%) had evidence of some type of hemorrhage on follow-up, compared to only 3 (27.3%) of the 11 who had MBs, and there was no significant difference in the type or frequency of hemorrhage (p = 0.18). Eight patients died within the 30-day follow-up period.