Clinical importance of microbleeds in patients receiving IV thrombolysis

Completed

Phase N/A Results

Trial Description

To determine if microbleeds (MBs) detected on gradient echo (GRE) imaging may be a risk factor for hemorrhagic complications in patients with stroke treated with IV tissue plasminogen activator (tPA).

Interventions

Trial Design

Multi-center, open-label, pilot study.

Patient Involvement

Patients underwent baseline CT scan and then an MRI of the brain. All patients were treated with 0.9 mg/kg of IV tPA (10% bolus over 1 minute, followed by continuous infusion of the remaining dose over 60 minutes) as quickly as possible following their initial MRI scan, but no later than 6 hours from the onset of their stroke symptoms.

Outcomes

Type Measure Time Frame Safety Issue
Primary Number and frequency of hemorrhagic complications.

Sponsors

NIH