To determine if microbleeds (MBs) detected on gradient echo (GRE) imaging may be a risk factor for hemorrhagic complications in patients with stroke treated with IV tissue plasminogen activator (tPA).
- Tissue plasminogen activator (Activase®)Drug
Other Names: rtpa Intervention Desc: Thrombolytic
Multi-center, open-label, pilot study.
Patients underwent baseline CT scan and then an MRI of the brain. All patients were treated with 0.9 mg/kg of IV tPA (10% bolus over 1 minute, followed by continuous infusion of the remaining dose over 60 minutes) as quickly as possible following their initial MRI scan, but no later than 6 hours from the onset of their stroke symptoms.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Number and frequency of hemorrhagic complications.|