Clinical Application and Basic Study of Medicinal Fractions-based Herbal Combinations

Completed

Phase N/A Results N/A

Trial Description

The purpose of this study is to investigate the efficacy of fractions-based herbal combinations of clearing heat and promoting blood circulation treating acute ischemic stroke and the potential mechanism of it.

Detailed Description

The interaction between fire-heat and blood stasis is a significant mechanism underlying pathogenesis and progress in acute ischemic stroke according to TCM theory.Clinical therapeutic effects are achieved with wide application of Ixeris of sonchifolia Hance components (KDZ injection) representing method of clearing heat and Panax notoginseng saponins components (Xueshuantong injection) representing method of promoting blood circulation.

Conditions

Interventions

  • Ixeris of sonchifolia Hance Drug
    Other Names: KDZ injection
    Intervention Desc: KDZ40ml+0.9%N.S.250ml,ivdrip,qd of each 14-day cycle.Number of cycles:one.
    ARM 1: Kind: Experimental
    Label: Clearing heat
    Description: Treat with KDZ injection on the basis of the basic treatment
  • Panax notoginseng saponins Drug
    Other Names: Xueshuantong injections
    Intervention Desc: Xueshuantong450mg+0.9%N.S.250ml,ivdrip,qd of each 14-day cycle.Number of cycles:one.
    ARM 1: Kind: Experimental
    Label: Promoting blood circulation
    Description: Treat with Xueshuantong injection on the basis of the basic treatment
  • Ixeris of sonchifolia Hance combined with Panax notoginseng saponins Drug
    Intervention Desc: KDZ40ml+0.9%N.S.250ml,ivdrip;0.9%N.S.50ml,ivdrip;Xueshuantong450mg+0.9%N.S.250ml,ivdrip.qd of each 14-day cycle.Number of cycles:one.
    ARM 1: Kind: Experimental
    Label: Clearing heat & Promoting blood circulation
    Description: Treat with both KDZ injection and Xueshuantong injection on the basis of the basic treatment
  • Ixeris of sonchifolia Hance combined with Panax notoginseng saponins Drug
    Intervention Desc: KDZ40ml+0.9%N.S.250ml,ivdrip;0.9%N.S.50ml,ivdrip;Xueshuantong450mg+0.9%N.S.250ml,ivdrip.qd of each 14-day cycle.Number of cycles:one.
    ARM 1: Kind: Experimental
    Label: Clearing heat & Promoting blood circulation
    Description: Treat with both KDZ injection and Xueshuantong injection on the basis of the basic treatment

Trial Design

  • Allocation: Randomized
  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Safety/Efficacy Study
  • Intervention: Factorial Assignment

Outcomes

Type Measure Time Frame Safety Issue
No outcomes associated with this trial.

Sponsors