To evaluate the effectiveness of citicoline in acute stroke.
- Citicoline (CerAxon®)Drug
Other Names: CDP-choline Intervention Desc: Phosphatidylcholine precursor, membrane stabilizer (cytidyl diphosphocholine)
Randomized (3 doses of citicoline to 1 placebo), vehicle-controlled, double-blind trial involving 259 patients at 21 centers.
Patients were randomized to receive either placebo or citicoline tablets at doses of either 500 mg once a day, 500 mg bid, or 1000 mg bid.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Barthel Index at 12 weeks.|
|Secondary||Percentage of patients with a favorable outcome (Barthel Index of 95 or 100 at 12 weeks), assessment of differences between each dose level and placebo on the Modified Rankin scale, neuropsychological test battery, NIHSS score <=1, number of days from stroke to hospital discharge.|