CHInese Medicine NeuroAid Efficacy on Stroke Recovery "CHIMES"


Phase 3 Results N/A

Eligibility Criteria

Inclusion Criteria

- Subject is aged 18 years old and above (for Singapore 21 years and above as this is the legal age of consent)
- Subject is on anti-platelet therapy
- Subject is presented a pre-stroke Modified Rankin Scale inferior or equal to 1
- Female subject is eligible to participate in the trial if she is of non-childbearing potential (i.e. physiologically incapable of becoming pregnant, including any female who is post menopausal)
- Subject or his/her legally acceptable representative is willing to provide written informed consent
- Subject is presented with cerebral infarction with compatible imaging at Computed Tomography (CT) scan or Magnetic Resonance Imaging (MRI)
- Time window is less than 72 hours after symptoms onset
- Subject with cerebral infarction with intermediate severity range: 6 ≤ NIHSS ≤ 14

Exclusion Criteria

- Subjects deemed unstable by investigator after thrombolysis treatment
- Subject has evidence of intra-cerebral hemorrhage on brain CT scan or MRI
- Subject has a rapidly improving neurological deficit
- Subject has definite indication for full-dose or long-term anticoagulation therapy
- Subject has other significant non-ischemic brain lesion which could affect function disability
- Subject has co-existing systemic diseases: terminal cancer, renal failure (creatinine > 200 μmol/L, if known), cirrhosis, severe dementia or psychosis
- Subject has participated in another clinical trial within the last three months