Inclusion Criteria1. ≥18 years old
2. elapsed time from last episode to registry <48 hours
Exclusion Criteria1. patients who refused to participate in the research, and patients who failed to complete the follow-up protocol.
2. patients with malignant tumors, or patients with severe liver or kidney disease, whose life expectancy is less than 1 year.
3. patients who received endovascular or thrombolytic therapy.