Characterizing Hemodynamic Compensation in Patients With Intracranial Stenosis "VAMMPRIS"


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

1. Adult patients (age 18-85, inclusive)
2. Symptomatic (TIA or ischemic stroke) in the hemispheric carotid territory of vascular stenosis
3. Vascular imaging demonstrating large vessel IC stenosis>50% or occlusion of IC carotid or MCA
4. Sub-acute stroke patients who have received intravenous or intra-arterial treatments
5. Sub-acute stroke patients ineligible for conventional acute stroke intervention. Language comprehension intact, motor aphasia mild or absent, competent to give informed consent
6. Most recent qualifying TIA or stroke within 60 days prior to performance date of hemodynamic MRI

Exclusion Criteria

1. ECA stenosis > 70% determined by MRA, CTA, or DSA.
2. Acute stroke patients presenting with anterior circulation stroke onset eligible for intervention with intra-arterial thrombolysis or mechanical thrombectomy
3. MRI contraindications (e.g. non-compatible implants, pregnancy, etc.)
4. Non-atherosclerotic cervical or intracranial stenosis
5. Heart disease likely to cause cerebral ischemia, including cardiomyopathy with ejection fraction<25%, prosthetic valve, infective endocarditis, sick sinus syndrome, myxoma, left atrial or ventricular thrombus
6. Existing condition likely to lead to death within 2 years