Changes in Sensitivity, Taste and Smell in Stroke Patients "5S"

Not yet recruiting

Phase N/A Results N/A

Trial Description

This study evaluates changes in swallowing using endoscopic swallowing studies and measuring of pharyngeal sensitivity, taste and smell in stroke patients. Younger (<60 years) and older (>60 years) volunteers will serve as control.

Detailed Description

Stroke is the second leading cause of death. At least 50% of stroke patients develop dysphagia, leading to aspiration pneumonia, which is the main cause of death in stroke (Kidd 1993).
It is assumed that normal sensitivity is vital for aspiration-free swallowing and for the triggering of the swallowing reflex.
Ali et al. demonstrated aspiration-free swallowing in healthy volunteers who underwent local anaesthesia of oral and pharyngeal structures (Ali 1994). Power et al. showed a reduced sensitivity of pharyngeal structures in stroke patients prone to aspiration (Power 2009).
By combining measuring sensitivity and flexible endoscopic swallowing studies, this study further investigates the role of sensitivity in swallowing Neuropsychological deficits of swallowing, such as swallowing apraxia or buccal hemineglect, is assessed by neuropsychological testing.
Additionally, there is no systematic research investigating the change in smell and taste in correlation with changes in stroke patients

Conditions

Interventions

  • Neuropsychological testing Diagnostic Test
    Intervention Desc: Neuropsychological testing for neglect, agnosia
    ARM 1: Kind: Experimental
    Label: Stroke patients
    Description: Stroke patients with supratentorial stroke, who are able to consent to participation in the study.
  • FEES (flexible endoscopic evaluation of swallowing) Diagnostic Test
    Intervention Desc: Endoscopical swallowing study in stroke patients only
    ARM 1: Kind: Experimental
    Label: Stroke patients
    Description: Stroke patients with supratentorial stroke, who are able to consent to participation in the study.
  • Sensitivity threshold Other
    Intervention Desc: Determining sensitivity threshold using a pudendal electrode
    ARM 1: Kind: Experimental
    Label: Volunteers <60 years
    Description: Volunteers, who are able to consent to participation in the study, as control.
    ARM 2: Kind: Experimental
    Label: Volunteers >60 years
    Description: Volunteers, who are able to consent to participation in the study, as control.
    ARM 3: Kind: Experimental
    Label: Stroke patients
    Description: Stroke patients with supratentorial stroke, who are able to consent to participation in the study.
  • Taste-/smell-test Diagnostic Test
    Intervention Desc: Taste-/smell-test
    ARM 1: Kind: Experimental
    Label: Volunteers <60 years
    Description: Volunteers, who are able to consent to participation in the study, as control.
    ARM 2: Kind: Experimental
    Label: Volunteers >60 years
    Description: Volunteers, who are able to consent to participation in the study, as control.
    ARM 3: Kind: Experimental
    Label: Stroke patients
    Description: Stroke patients with supratentorial stroke, who are able to consent to participation in the study.

Trial Population

Stroke patients are recruited in a university hospital's department of neurology. Volunteers >60years are recruited in a trauma surgery ward at the same university hospital. Volunteers <60 are recruited without specified characteristics (aside from in-/exclusion criteria).

Outcomes

Type Measure Time Frame Safety Issue
Primary Dysphagia 96 hours after initial symptoms
Secondary Neuropsychological deficits 96 hours after initial symptoms
Secondary Lesion site 96 hours after initial symptoms
Secondary Sensitivity 96 hours after initial symptoms
Secondary Taste/Smell 96 hours after initial symptoms

Sponsors