Cerebral Reorganization of Stroke Patients After Repetitive Transcranial Magnetic Stimulation by Neuroimaging Analysis

Recruiting

Phase N/A Results N/A

Trial Description

The study aimed to figure out brain structural and functional reorganization evidence after repetitive transcranial magnetic stimulation through the method of neuroimaging brain network analysis, such as resting-state functional magnetic resonance imaging and diffusion tensor imaging.

Conditions

Interventions

  • Sham repetitive Transcranial Magnetic Stimulation Device
    Intervention Desc: The sham rTMS was performed on the same site as the rTMS treatment group but without any true stimulations. Coils were placed perpendicular to the scalp.
    ARM 1: Kind: Experimental
    Label: sham group
    Description: The sham group received a 10-day sham repetitive transcranial magnetic stimulation (rTMS) treatment beginning within 1 week after stroke onset.
  • Real Repetitive Transcranial Magnetic Stimulation Device
    Intervention Desc: The rTMS treatments were performed using a Medtronic MagPro type magnetic stimulation device (Medtronic, Minneapolis, MN, USA) and a figure-of-eight coil (MC-B70, Medtronic). Coils were placed tangent to the scalp. The stimulation protocol involved 50 trains of 20 pulses applied over the ipsilesional M1 at a frequency of 5 HZ, with the stimulus intensity set at 120% of the resting motor threshold of the unaffected extremity.
    ARM 1: Kind: Experimental
    Label: rTMS treatment group
    Description: The rTMS treatment group received a 10-day real repetitive transcranial magnetic stimulation (rTMS) treatment beginning within 1 week after stroke onset.

Outcomes

Type Measure Time Frame Safety Issue
Primary National Institutes of Health Stroke Scale (NIHSS) Change from Baseline NIHSS at 1 month after real rTMS/sham rTMS
Primary Barthel Index (BI) Change from Baseline BI at 1 month after real rTMS/sham rTMS
Primary Fugl-Meyer assessment (FMA) Change from Baseline FMA at 1 month after real rTMS/sham rTMS
Secondary functional connectivity (FC) Change from Baseline FC at 1 month after real rTMS/sham rTMS

Sponsors