Cerebral Lesions and Outcome After Cardiac Surgery (CLOCS)


Phase N/A Results N/A

Eligibility Criteria

- Age 18 years or greater
- Neurologically and cognitively independent prior to surgery (mRS less than 2)
- CABG, aortic or mitral valve replacement, or a combined valve/CABG procedure scheduled within one week
- Planned concomitant carotid endarterectomy
- Concomitant medical disorders making clinical follow-up of at least 6 months unlikely or impossible (e.g., neoplastic disease, hepatic failure)
- History of dementia, cognitive dysfunction (MMSE score less than 24) or psychotic disorder
- Any current MRI contraindication (cardiac pacemaker or defibrillator, insulin pump, aneurysmal clip, implanted neural stimulator, cochlear implant, metal shrapnel or bullet, etc)
- Definite or possible pacemaker placement at the time of or after surgery
- Inability to give informed consent
- Pregnancy