Cerebral Infarction and White Substance in Angiopathy Cerebral Amyloid

Active, not recruiting

Phase N/A Results N/A

Trial Description

The cerebral amyloïd angiopathy ( AAC) is a disease characterized by deposits of beta-amyloid peptids in the walls of the arteries of young and average calibre of the brain and the leptomeninx. The incidence of the AAC increases strongly with the age and represents a major cause of spontaneous brain haemorrhage to people over 60. The main demonstration is the lobar brain haemorrhage, the other ones are bleedings under arachnoid cortical and microbleedings leading to cognitive decline.
Anatomical studies reported the presence of cortical infarcts in patients having amyloïd deposits suggesting an association between asymptomatic cortical cerebral infarcts and AAC.
However prevalence and meaning of these infarcts in patients having an AAC remain badly known because of studies on low number of patients and the rarity of radiological analyses of these infarcts .A better knowledge of these asymptomatic cortical infarcts would allow to dread better cognitive disorders(confusions) presented by these patients, and to develop preventive strategies.
Besides, the risk factors of severity of the AAC are little studied.



  • Medical report consultation Other
    Intervention Desc: investigators consult medical report concerning patient identified for cerebral amyloid angiopathy

Trial Population

Investigators select medical report of hospitalized patient between 2011/01/01 and 2015/12/31 in CAEN hospital and Paris St Joseph hospital ; these had an MRI for cerebral haemorrhage.


Type Measure Time Frame Safety Issue
Primary number of patient with cerebral infarction and associated factors in a cohort of cerebral amyloid angiopathy patients 1day