Carotid Plaque Imaging in Acute Stroke "CAPIAS"


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- Age > 49 years old
- Acute ischemic stroke or transient ischemic attack (TIA)
- Neurological symptoms compatible with a stroke or TIA in the anterior circulation (territory of the internal carotid artery)
- Onset of symptoms within the last 7 days
- 1 or more acute ischemic lesion(s) visible on MR diffusion-weighted imaging (DWI) in the territory of a single internal carotid artery
- Presence of carotid artery plaques in the ipsilateral or contralateral carotid artery as defined by ultrasound (criteria: plaque thickness at least 2mm; located within 1cm proximal or distal to the carotid bifurcation)
- Written informed consent

Exclusion Criteria

- Primary referral to an outside hospital (to avoid recruitment bias)
- DWI positive lesions outside the territory of a single internal carotid artery
- Carotid artery stenosis > 69% (North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria) ipsilateral to the stroke or TIA as defined by ultrasound (systolic peak flow velocity ≥ 300 cm/s)
- Standard contra-indications for MRI
- Documented allergy to MRI contrast media
- History of radiation to the neck area
- Renal clearance < 30 ml/minute
- Creatinine levels > 2 times the upper limit of the standard range of the respective laboratory within the last 30 days prior to MRI
- Surgical procedure within 24 hours preceding the MRI