Carotid Plaque Assessment Using 18Fluorine (18F) -Sodium Fluoride Positron Emission Tomography (PET) /MR "CARTIS"

Completed

Phase N/A Results N/A

Update History

10 Jan '18
The Summary of Purpose was updated.
New
Carotid plaque can lead to ischemic stroke. Treatment of asymptomatic carotid plaque, based on degree stenosis, is still controversial. Beyond the degree of stenosis, the composition of the plaque could reflect the vulnerability and the risk of ipsilateral ischemic stroke. Identification of new predictive factor of ipsilateral ischemic stroke in patients with carotid plaque could help to screen high risk patients and to guide the treatment. The aim of the study is to assess 18F-sodium fluoride uptake among carotid plaque in recently symptomatic and asymptomatic patients. Investigators conduct a pilot case-control study. Twelve patients (6 recently symptomatic and 6 asymptomatic) with carotid stenosis (≥50% NASCET) will have a 18F-sodium fluoride PET/MR. Standardized uptake value (SUV) and tissue-to-background ratio (TBR) will be measured among carotid plaques.
Old
Carotid plaque can lead to ischemic stroke. Treatment of asymptomatic carotid plaque, based on degree stenosis, is still controversial. Beyond the degree of stenosis, the composition of the plaque could reflect the vulnerability and the risk of ipsilateral ischemic stroke. Identification of new predictive factor of ipsilateral ischemic stroke in patients with carotid plaque could help to screen high risk patients and to guide the treatment. The aim of the study is to assess 18F-sodium fluoride uptake among carotid plaque in recently symptomatic and asymptomatic patients. Investigators conduct a pilot case-control study. Twelve patients (6 recently symptomatic and 6 asymptomatic) with carotid stenosis (≥50% NASCET) will have a 18F-sodium fluoride PET/MR. Standardized uptake value (SUV) and tissue-to-background ratio (TBR) will be measured among carotid plaques.
The eligibility criteria were updated.
New
Inclusion Criteria symptomatic patients: - age>18 - Carotid plaque ≥ 50% symptomatic (ischemic stroke on CT or MR) during the last 15 days or asymptomatic - ability to give informed consent - affiliation to social security Exclusion Criteria: - Modified Rankin score ˃ 3 - Contraindication to MRI - Renal failure (creatinine clearance by cockcroft ˂ 50 ml / min) - Pregnancy / Breastfeeding - Hypersensitivity to the active substance or excipients
Old
Inclusion Criteria symptomatic patients: - age>18 - Carotid plaque ≥ 50% symptomatic (ischemic stroke on CT or MR) during the last 15 days or asymptomatic - ability to give informed consent - affiliation to social security Exclusion Criteria: - Modified Rankin score ˃ 3 - Contraindication to MRI - Renal failure (creatinine clearance by cockcroft ˂ 50 ml / min) - Pregnancy / Breastfeeding - Hypersensitivity to the active substance or excipients
A location was updated in Bron.
New
The overall status was removed for Hospices Civils de Lyon.
3 Jun '17
The gender criteria for eligibility was updated to "All."