Carotid and Vertebral Transluminal Angioplasty Study "CAVATAS"

Completed

Phase N/A Results

Trial Description

To compare carotid angioplasty (with or without stenting) to carotid endarterectomy.

Interventions

  • Endarterectomy, carotid (CEA)Procedure/Surgery
    Intervention Desc: Surgical therapy to remove atherosclerotic plaque in narrowed carotid arteries.
  • Angioplasty, carotid Procedure/Surgery
    Intervention Desc: Intravascular procedure to dilate stenotic carotid arteries.

Trial Design

Randomized trial of 504 patients at 24 centers.

Patient Involvement

Patients were randomized to receive carotid angioplasty or carotid endarterectomy. Antiplatelet agents started 24 hrs before treatment and anticoagulation during and 24 hrs after treatment.

Outcomes

Type Measure Time Frame Safety Issue
Primary Recurrent stroke, death, restenosis and safety over 3 year period.
Secondary Any stroke or death within 30 days of treatment, myocardial infarction within 30 days of treatment, treatment-related cranial nerve palsy or haematoma requiring reoperation or prolonging hospital stay. Stenosis (>70%) and occlusion on ultrasound follow-up. Stroke during follow-up. Further treatment procedure. Quality of life and economic measures.

Sponsors

British Heart Foundation, National Health Service Research and Development Programme