To compare carotid angioplasty (with or without stenting) to carotid endarterectomy.
- Endarterectomy, carotid (CEA)Procedure/Surgery
Intervention Desc: Surgical therapy to remove atherosclerotic plaque in narrowed carotid arteries.
- Angioplasty, carotid Procedure/Surgery
Intervention Desc: Intravascular procedure to dilate stenotic carotid arteries.
Randomized trial of 504 patients at 24 centers.
Patients were randomized to receive carotid angioplasty or carotid endarterectomy. Antiplatelet agents started 24 hrs before treatment and anticoagulation during and 24 hrs after treatment.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Recurrent stroke, death, restenosis and safety over 3 year period.|
|Secondary||Any stroke or death within 30 days of treatment, myocardial infarction within 30 days of treatment, treatment-related cranial nerve palsy or haematoma requiring reoperation or prolonging hospital stay. Stenosis (>70%) and occlusion on ultrasound follow-up. Stroke during follow-up. Further treatment procedure. Quality of life and economic measures.|