Cardiovascular Safety of Febuxostat and Allopurinol in Patients With Gout and Cardiovascular Comorbidities "CARES"

Completed

Phase 3 Results N/A

Update History

12 Aug '17
The Summary of Purpose was updated.
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The purpose of this study is to see whether subjects with gout who receive febuxostat or allopurinol for up to 9 years have a higher rate of serious heart and blood vessel complications (major cardiovascular events). Examples of major cardiovascular events include heart attacks, strokes, and angina (chest pain due to narrowing of the blood vessels of the heart) that need to be treated urgently with a heart operation. The overall duration of the study is dependent on the number of predefined major cardiovascular events (MACE). The length of study is expected to be approximately 9 years in order to observe the required 624 MACE. The length of study participation for each subject will vary due to the event driven study design. The purpose of this study is to see if subjects with gout who receive febuxostat or allopurinol, once daily (QD), have a higher rate of serious heart and blood vessel complications.
Old
The purpose of this study is to see whether subjects with gout who receive febuxostat or allopurinol for up to 9 years have a higher rate of serious heart and blood vessel complications (major cardiovascular events). Examples of major cardiovascular events include heart attacks, strokes, and angina (chest pain due to narrowing of the blood vessels of the heart) that need to be treated urgently with a heart operation. The overall duration of the study is dependent on the number of predefined major cardiovascular events (MACE). The length of study is expected to be approximately 9 years in order to observe the required 624 MACE. The length of study participation for each subject will vary due to the event driven study design. The purpose of this study is to see if subjects with gout who receive febuxostat or allopurinol, once daily (QD), have a higher rate of serious heart and blood vessel complications.
The description was updated.
New
This is a phase 3B multicenter, randomized, double-blind, active-controlled study designed to evaluate the cardiovascular (CV) safety of febuxostat compared with allopurinol in subjects with gout and significant CV comorbidities. Approximately 7500 subjects, males 50 years of age or older or females 55 years of age or older (at least 2-years post-menopausal), with gout and health problems affecting the heart or blood vessels will take part in this study at approximately 450 study centers in North America. This study will use competitive enrollment. This means that when a target number of subjects has entered the treatment phase of the study, all further screening of subjects will be closed. The length of the study is based on an ongoing review of study results. The participation will last a maximum of 9 years and will include a maximum 28 visits to the study center. Telephone contact will be made every 2 months for subjects who have discontinued the study drug for any reason, but who are asked to continue in the study to be followed for potential cardiovascular events. This study design is called a "Time to Event Study". All study subjects will continue to be followed until enough information has been gathered to determine the overall safety of the study drug. Gout is caused by high levels of uric acid in the body, and is associated with a broad range of conditions including heart disease, chronic kidney disease and additional risk factors like obesity and high blood pressure. Hyperuricemia, which is defined as an elevation in serum urate levels, develops into gout when urate crystals form from supersaturated body fluids and settle in joints and other organs. People with gout may also have a higher incidence of other conditions that may be associated with hyperuricemia, gout or both. This is supported by a growing body of research demonstrating that serum urate levels are an independent predictive factor for cardiovascular disease when the effects of other risk factors have been controlled. This study will explore the cardiovascular safety of febuxostat to determine whether the use of febuxostat is associated with a moderate increase in the risk of serious adverse cardiovascular outcomes as compared to allopurinol. Participation will last a maximum of 5 years and will include 15 to 20 visits to the study center.
Old
This is a phase 3B multicenter, randomized, double-blind, active-controlled study designed to evaluate the cardiovascular (CV) safety of febuxostat compared with allopurinol in subjects with gout and significant CV comorbidities. Approximately 7500 subjects, males 50 years of age or older or females 55 years of age or older (at least 2-years post-menopausal), with gout and health problems affecting the heart or blood vessels will take part in this study at approximately 450 study centers in North America. This study will use competitive enrollment. This means that when a target number of subjects has entered the treatment phase of the study, all further screening of subjects will be closed. The length of the study is based on an ongoing review of study results. The participation will last a maximum of 9 years and will include a maximum 28 visits to the study center. Telephone contact will be made every 2 months for subjects who have discontinued the study drug for any reason, but who are asked to continue in the study to be followed for potential cardiovascular events. This study design is called a "Time to Event Study". All study subjects will continue to be followed until enough information has been gathered to determine the overall safety of the study drug. Gout is caused by high levels of uric acid in the body, and is associated with a broad range of conditions including heart disease, chronic kidney disease and additional risk factors like obesity and high blood pressure. Hyperuricemia, which is defined as an elevation in serum urate levels, develops into gout when urate crystals form from supersaturated body fluids and settle in joints and other organs. People with gout may also have a higher incidence of other conditions that may be associated with hyperuricemia, gout or both. This is supported by a growing body of research demonstrating that serum urate levels are an independent predictive factor for cardiovascular disease when the effects of other risk factors have been controlled. This study will explore the cardiovascular safety of febuxostat to determine whether the use of febuxostat is associated with a moderate increase in the risk of serious adverse cardiovascular outcomes as compared to allopurinol. Participation will last a maximum of 5 years and will include 15 to 20 visits to the study center.
The gender criteria for eligibility was updated to "All."
The eligibility criteria were updated.
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Inclusion Criteria: 1. The subject or the subject's legally acceptable representative signs and dates a written, informed consent form/Health Insurance Portability and Accountability Act (HIPAA) Authorization prior to the initiation of any study procedures. 2. The subject is male ≥50 years of age or female ≥55 years of age and at least 2-years post-menopausal. 3. The subject has a history of major CV or cerebrovascular disease including at least one of the following: - MI. - Hospitalized unstable angina. - Cardiac or cerebrovascular revascularization procedure. - Stroke. - Hospitalized TIA. - Peripheral vascular disease (ankle brachial index ≤0.6, revascularization and/or well-documented history of claudication). - History of diabetes mellitus with evidence of micro- or macrovascular disease (retinopathy, neuropathy, nephropathy, small vessel vascular diseases). 4. The subject has a history or presence of gout defined as having one or more of the American Rheumatism Association criteria for the diagnosis of gout: - A tophus proven to contain urate crystals by chemical or polarized light microscopic means, and/or - Characteristic urate crystals in the joint fluid, and/or - History of at least 6 of the following clinical, laboratory, and x-ray phenomena: - More than 1 attack of acute arthritis. - Maximum inflammation developed within 1 day. - Monoarticular arthritis. - Redness observed over joints. - First metatarsophalangeal joint painful or swollen. - Unilateral first metatarsophalangeal joint attack. - Unilateral tarsal joint attack. - Tophus (proven or suspected). - Hyperuricemia. - Asymmetric swelling within a joint on x-ray. - Subcortical cysts without erosions on x-ray. - Joint fluid culture negative for organisms during attack. 5. The subjects must have either: - a sUA level ≥7.0 mg/dL (≥416 μmol/L) at the Day -7 Visit OR - a sUA level ≥6.0 mg/dL (≥354 μmol/L) at the Day -7 Visit AND inadequately controlled gout (≥1 flare in the 12 months prior to screening and/or the presence of tophi). 6. The subject is capable of understanding and complying with protocol requirements Exclusion Criteria: Subjects who meet any of the following criteria will not qualify for entry into this study: 1. The subject has secondary hyperuricemia (eg, due to myeloproliferative disorder, or organ transplant). 2. The subject has a history of xanthinuria. 3. The subject has received urate-lowering therapy (i.e., febuxostat, allopurinol, probenecid, etc.) or excluded medication during the screening period (beginning with Day -7). 4. The subject has a known hypersensitivity to febuxostat or allopurinol or any components of their formulation. 5. The subject has active peptic ulcer disease. 6. The subject has a history of cancer (other than basal cell carcinoma of the skin) within 5 years prior to the first dose of study medication. 7. The subject had MI or stroke within 60 days prior to the Screening Visit. 8. The subject has ALT and/or AST values greater than 2 times the upper limit of normal (×ULN) during the Screening period. 9. The subject has a significant medical condition and/or conditions that would interfere with the treatment, safety, or compliance with the protocol. 10. The subject has a history of drug abuse (defined as any illicit drug use) or a history of alcohol abuse within 5 years prior to the Screening Visit or the subject consumes >14 alcoholic beverages per week. 11. The subject has received any investigational medicinal product within the 30 days prior to the Screening Visit and throughout the study. 12. The subject's estimated CLcr is <30 mL/min, where CLcr is calculated using the Cockcroft and Gault formula based on ideal body weight (IBW), 13. The subject is an immediate family member, study site employee, or is in a dependant relationship with a study site employee who is involved in conduct of this study (eg, spouse, parent, child, sibling) or may consent under duress. 14. The subject is required to take excluded medications 15. The subject has a known history of infection with hepatitis B, hepatitis C, or human immunodeficiency virus. Inclusion Criteria: - Has a history of major cardiovascular or cerebrovascular disease including at least one of the following: - Myocardial infarction - Hospitalized unstable angina - Cardiac or cerebrovascular revascularization procedure - Stroke - Hospitalized for transient ischemic attack - Peripheral vascular disease - History of diabetes mellitus with evidence of micro- or macrovascular disease - Has a history or presence of gout defined as having one or more of the American Rheumatism Association criteria for the diagnosis of gout: - A tophus proven to contain urate crystals by chemical or polarized light microscopic means, and/or - Characteristic urate crystals in the joint fluid, and/or - History of at least 6 of the following clinical, laboratory, and x-ray phenomena: - More than 1 attack of acute arthritis - Maximum inflammation developed within 1 day - Monoarticular arthritis - Redness observed over joints - First metatarsophalangeal joint painful or swollen - Unilateral first metatarsophalangeal joint attack - Unilateral tarsal joint attack - Tophus (proven or suspected) - Hyperuricemia - Asymmetric swelling within a joint on x-ray - Subcortical cysts without erosions on x-ray - Joint fluid culture negative for organisms during attack - Must have either: - a serum urate level greater than or equal to 7.0 mg/dL at the Day -7 Visit OR - a serum urate level greater than or equal to 6.0 mg/dL at the Day -7 Visit AND inadequately controlled gout Exclusion Criteria: - Has secondary hyperuricemia - Has a history of xanthinuria - Has received urate-lowering or excluded medication during the screening period - Has a known hypersensitivity to febuxostat or allopurinol or any components of their formulation - Has active peptic ulcer disease - Has a history of cancer within 5 years prior to the first dose of study medication - Had a myocardial infarction or stroke within 60 days prior to the Screening Visit - Has alanine aminotransferase and/or aspartate aminotransferase values greater than 2 times the upper limit of normal during the Screening period - Has a history of drug abuse or a history of alcohol abuse within 5 years prior to the Screening Visit or the subject consumes more than14 alcoholic beverages per week - Has received any investigational medicinal product within the 30 days prior to the Screening Visit and throughout the study - Has an estimated creatinine clearance less than 30 mL/min - Is required to take excluded medications - Has a known history of infection with hepatitis B, hepatitis C, or human immunodeficiency virus
Old
Inclusion Criteria: 1. The subject or the subject's legally acceptable representative signs and dates a written, informed consent form/Health Insurance Portability and Accountability Act (HIPAA) Authorization prior to the initiation of any study procedures. 2. The subject is male ≥50 years of age or female ≥55 years of age and at least 2-years post-menopausal. 3. The subject has a history of major CV or cerebrovascular disease including at least one of the following: - MI. - Hospitalized unstable angina. - Cardiac or cerebrovascular revascularization procedure. - Stroke. - Hospitalized TIA. - Peripheral vascular disease (ankle brachial index ≤0.6, revascularization and/or well-documented history of claudication). - History of diabetes mellitus with evidence of micro- or macrovascular disease (retinopathy, neuropathy, nephropathy, small vessel vascular diseases). 4. The subject has a history or presence of gout defined as having one or more of the American Rheumatism Association criteria for the diagnosis of gout: - A tophus proven to contain urate crystals by chemical or polarized light microscopic means, and/or - Characteristic urate crystals in the joint fluid, and/or - History of at least 6 of the following clinical, laboratory, and x-ray phenomena: - More than 1 attack of acute arthritis. - Maximum inflammation developed within 1 day. - Monoarticular arthritis. - Redness observed over joints. - First metatarsophalangeal joint painful or swollen. - Unilateral first metatarsophalangeal joint attack. - Unilateral tarsal joint attack. - Tophus (proven or suspected). - Hyperuricemia. - Asymmetric swelling within a joint on x-ray. - Subcortical cysts without erosions on x-ray. - Joint fluid culture negative for organisms during attack. 5. The subjects must have either: - a sUA level ≥7.0 mg/dL (≥416 μmol/L) at the Day -7 Visit OR - a sUA level ≥6.0 mg/dL (≥354 μmol/L) at the Day -7 Visit AND inadequately controlled gout (≥1 flare in the 12 months prior to screening and/or the presence of tophi). 6. The subject is capable of understanding and complying with protocol requirements Exclusion Criteria: Subjects who meet any of the following criteria will not qualify for entry into this study: 1. The subject has secondary hyperuricemia (eg, due to myeloproliferative disorder, or organ transplant). 2. The subject has a history of xanthinuria. 3. The subject has received urate-lowering therapy (i.e., febuxostat, allopurinol, probenecid, etc.) or excluded medication during the screening period (beginning with Day -7). 4. The subject has a known hypersensitivity to febuxostat or allopurinol or any components of their formulation. 5. The subject has active peptic ulcer disease. 6. The subject has a history of cancer (other than basal cell carcinoma of the skin) within 5 years prior to the first dose of study medication. 7. The subject had MI or stroke within 60 days prior to the Screening Visit. 8. The subject has ALT and/or AST values greater than 2 times the upper limit of normal (×ULN) during the Screening period. 9. The subject has a significant medical condition and/or conditions that would interfere with the treatment, safety, or compliance with the protocol. 10. The subject has a history of drug abuse (defined as any illicit drug use) or a history of alcohol abuse within 5 years prior to the Screening Visit or the subject consumes >14 alcoholic beverages per week. 11. The subject has received any investigational medicinal product within the 30 days prior to the Screening Visit and throughout the study. 12. The subject's estimated CLcr is <30 mL/min, where CLcr is calculated using the Cockcroft and Gault formula based on ideal body weight (IBW), 13. The subject is an immediate family member, study site employee, or is in a dependant relationship with a study site employee who is involved in conduct of this study (eg, spouse, parent, child, sibling) or may consent under duress. 14. The subject is required to take excluded medications 15. The subject has a known history of infection with hepatitis B, hepatitis C, or human immunodeficiency virus. Inclusion Criteria: - Has a history of major cardiovascular or cerebrovascular disease including at least one of the following: - Myocardial infarction - Hospitalized unstable angina - Cardiac or cerebrovascular revascularization procedure - Stroke - Hospitalized for transient ischemic attack - Peripheral vascular disease - History of diabetes mellitus with evidence of micro- or macrovascular disease - Has a history or presence of gout defined as having one or more of the American Rheumatism Association criteria for the diagnosis of gout: - A tophus proven to contain urate crystals by chemical or polarized light microscopic means, and/or - Characteristic urate crystals in the joint fluid, and/or - History of at least 6 of the following clinical, laboratory, and x-ray phenomena: - More than 1 attack of acute arthritis - Maximum inflammation developed within 1 day - Monoarticular arthritis - Redness observed over joints - First metatarsophalangeal joint painful or swollen - Unilateral first metatarsophalangeal joint attack - Unilateral tarsal joint attack - Tophus (proven or suspected) - Hyperuricemia - Asymmetric swelling within a joint on x-ray - Subcortical cysts without erosions on x-ray - Joint fluid culture negative for organisms during attack - Must have either: - a serum urate level greater than or equal to 7.0 mg/dL at the Day -7 Visit OR - a serum urate level greater than or equal to 6.0 mg/dL at the Day -7 Visit AND inadequately controlled gout Exclusion Criteria: - Has secondary hyperuricemia - Has a history of xanthinuria - Has received urate-lowering or excluded medication during the screening period - Has a known hypersensitivity to febuxostat or allopurinol or any components of their formulation - Has active peptic ulcer disease - Has a history of cancer within 5 years prior to the first dose of study medication - Had a myocardial infarction or stroke within 60 days prior to the Screening Visit - Has alanine aminotransferase and/or aspartate aminotransferase values greater than 2 times the upper limit of normal during the Screening period - Has a history of drug abuse or a history of alcohol abuse within 5 years prior to the Screening Visit or the subject consumes more than14 alcoholic beverages per week - Has received any investigational medicinal product within the 30 days prior to the Screening Visit and throughout the study - Has an estimated creatinine clearance less than 30 mL/min - Is required to take excluded medications - Has a known history of infection with hepatitis B, hepatitis C, or human immunodeficiency virus
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13 Jul '16
The Summary of Purpose was updated.
New
The purpose of this study is to see whether subjects with gout who receive febuxostat or allopurinol for up to 9 years have a higher rate of serious heart and blood vessel complications (major cardiovascular events). Examples of major cardiovascular events include heart attacks, strokes, and angina (chest pain due to narrowing of the blood vessels of the heart) that need to be treated urgently with a heart operation. The overall duration of the study is dependent on the number of predefined major cardiovascular events (MACE). The length of study is expected to be approximately 9 years in order to observe the required 624 MACE. The length of study participation for each subject will vary due to the event driven study design. The purpose of this study is to see if subjects with gout who receive febuxostat or allopurinol, once daily (QD), have a higher rate of serious heart and blood vessel complications.
Old
The purpose of this study is to see whether subjects with gout who receive febuxostat or allopurinol for up to 9 years have a higher rate of serious heart and blood vessel complications (major cardiovascular events). Examples of major cardiovascular events include heart attacks, strokes, and angina (chest pain due to narrowing of the blood vessels of the heart) that need to be treated urgently with a heart operation. The overall duration of the study is dependent on the number of predefined major cardiovascular events (MACE). The length of study is expected to be approximately 9 years in order to observe the required 624 MACE. The length of study participation for each subject will vary due to the event driven study design. The purpose of this study is to see if subjects with gout who receive febuxostat or allopurinol, once daily (QD), have a higher rate of serious heart and blood vessel complications.
The description was updated.
New
This is a phase 3B multicenter, randomized, double-blind, active-controlled study designed to evaluate the cardiovascular (CV) safety of febuxostat compared with allopurinol in subjects with gout and significant CV comorbidities. Approximately 7500 subjects, males 50 years of age or older or females 55 years of age or older (at least 2-years post-menopausal), with gout and health problems affecting the heart or blood vessels will take part in this study at approximately 450 study centers in North America. This study will use competitive enrollment. This means that when a target number of subjects has entered the treatment phase of the study, all further screening of subjects will be closed. The length of the study is based on an ongoing review of study results. The participation will last a maximum of 9 years and will include a maximum 28 visits to the study center. Telephone contact will be made every 2 months for subjects who have discontinued the study drug for any reason, but who are asked to continue in the study to be followed for potential cardiovascular events. This study design is called a "Time to Event Study". All study subjects will continue to be followed until enough information has been gathered to determine the overall safety of the study drug. Gout is caused by high levels of uric acid in the body, and is associated with a broad range of conditions including heart disease, chronic kidney disease and additional risk factors like obesity and high blood pressure. Hyperuricemia, which is defined as an elevation in serum urate levels, develops into gout when urate crystals form from supersaturated body fluids and settle in joints and other organs. People with gout may also have a higher incidence of other conditions that may be associated with hyperuricemia, gout or both. This is supported by a growing body of research demonstrating that serum urate levels are an independent predictive factor for cardiovascular disease when the effects of other risk factors have been controlled. This study will explore the cardiovascular safety of febuxostat to determine whether the use of febuxostat is associated with a moderate increase in the risk of serious adverse cardiovascular outcomes as compared to allopurinol. Participation will last a maximum of 5 years and will include 15 to 20 visits to the study center.
Old
This is a phase 3B multicenter, randomized, double-blind, active-controlled study designed to evaluate the cardiovascular (CV) safety of febuxostat compared with allopurinol in subjects with gout and significant CV comorbidities. Approximately 7500 subjects, males 50 years of age or older or females 55 years of age or older (at least 2-years post-menopausal), with gout and health problems affecting the heart or blood vessels will take part in this study at approximately 450 study centers in North America. This study will use competitive enrollment. This means that when a target number of subjects has entered the treatment phase of the study, all further screening of subjects will be closed. The length of the study is based on an ongoing review of study results. The participation will last a maximum of 9 years and will include a maximum 28 visits to the study center. Telephone contact will be made every 2 months for subjects who have discontinued the study drug for any reason, but who are asked to continue in the study to be followed for potential cardiovascular events. This study design is called a "Time to Event Study". All study subjects will continue to be followed until enough information has been gathered to determine the overall safety of the study drug. Gout is caused by high levels of uric acid in the body, and is associated with a broad range of conditions including heart disease, chronic kidney disease and additional risk factors like obesity and high blood pressure. Hyperuricemia, which is defined as an elevation in serum urate levels, develops into gout when urate crystals form from supersaturated body fluids and settle in joints and other organs. People with gout may also have a higher incidence of other conditions that may be associated with hyperuricemia, gout or both. This is supported by a growing body of research demonstrating that serum urate levels are an independent predictive factor for cardiovascular disease when the effects of other risk factors have been controlled. This study will explore the cardiovascular safety of febuxostat to determine whether the use of febuxostat is associated with a moderate increase in the risk of serious adverse cardiovascular outcomes as compared to allopurinol. Participation will last a maximum of 5 years and will include 15 to 20 visits to the study center.
The eligibility criteria were updated.
New
Inclusion Criteria: 1. The subject or the subject's legally acceptable representative signs and dates a written, informed consent form/Health Insurance Portability and Accountability Act (HIPAA) Authorization prior to the initiation of any study procedures. 2. The subject is male ≥50 years of age or female ≥55 years of age and at least 2-years post-menopausal. 3. The subject has a history of major CV or cerebrovascular disease including at least one of the following: - MI. - Hospitalized unstable angina. - Cardiac or cerebrovascular revascularization procedure. - Stroke. - Hospitalized TIA. - Peripheral vascular disease (ankle brachial index ≤0.6, revascularization and/or well-documented history of claudication). - History of diabetes mellitus with evidence of micro- or macrovascular disease (retinopathy, neuropathy, nephropathy, small vessel vascular diseases). 4. The subject has a history or presence of gout defined as having one or more of the American Rheumatism Association criteria for the diagnosis of gout: - A tophus proven to contain urate crystals by chemical or polarized light microscopic means, and/or - Characteristic urate crystals in the joint fluid, and/or - History of at least 6 of the following clinical, laboratory, and x-ray phenomena: - More than 1 attack of acute arthritis. - Maximum inflammation developed within 1 day. - Monoarticular arthritis. - Redness observed over joints. - First metatarsophalangeal joint painful or swollen. - Unilateral first metatarsophalangeal joint attack. - Unilateral tarsal joint attack. - Tophus (proven or suspected). - Hyperuricemia. - Asymmetric swelling within a joint on x-ray. - Subcortical cysts without erosions on x-ray. - Joint fluid culture negative for organisms during attack. 5. The subjects must have either: - a sUA level ≥7.0 mg/dL (≥416 μmol/L) at the Day -7 Visit OR - a sUA level ≥6.0 mg/dL (≥354 μmol/L) at the Day -7 Visit AND inadequately controlled gout (≥1 flare in the 12 months prior to screening and/or the presence of tophi). 6. The subject is capable of understanding and complying with protocol requirements Exclusion Criteria: Subjects who meet any of the following criteria will not qualify for entry into this study: 1. The subject has secondary hyperuricemia (eg, due to myeloproliferative disorder, or organ transplant). 2. The subject has a history of xanthinuria. 3. The subject has received urate-lowering therapy (i.e., febuxostat, allopurinol, probenecid, etc.) or excluded medication during the screening period (beginning with Day -7). 4. The subject has a known hypersensitivity to febuxostat or allopurinol or any components of their formulation. 5. The subject has active peptic ulcer disease. 6. The subject has a history of cancer (other than basal cell carcinoma of the skin) within 5 years prior to the first dose of study medication. 7. The subject had MI or stroke within 60 days prior to the Screening Visit. 8. The subject has ALT and/or AST values greater than 2 times the upper limit of normal (×ULN) during the Screening period. 9. The subject has a significant medical condition and/or conditions that would interfere with the treatment, safety, or compliance with the protocol. 10. The subject has a history of drug abuse (defined as any illicit drug use) or a history of alcohol abuse within 5 years prior to the Screening Visit or the subject consumes >14 alcoholic beverages per week. 11. The subject has received any investigational medicinal product within the 30 days prior to the Screening Visit and throughout the study. 12. The subject's estimated CLcr is <30 mL/min, where CLcr is calculated using the Cockcroft and Gault formula based on ideal body weight (IBW), 13. The subject is an immediate family member, study site employee, or is in a dependant relationship with a study site employee who is involved in conduct of this study (eg, spouse, parent, child, sibling) or may consent under duress. 14. The subject is required to take excluded medications 15. The subject has a known history of infection with hepatitis B, hepatitis C, or human immunodeficiency virus. Inclusion Criteria: - Has a history of major cardiovascular or cerebrovascular disease including at least one of the following: - Myocardial infarction - Hospitalized unstable angina - Cardiac or cerebrovascular revascularization procedure - Stroke - Hospitalized for transient ischemic attack - Peripheral vascular disease - History of diabetes mellitus with evidence of micro- or macrovascular disease - Has a history or presence of gout defined as having one or more of the American Rheumatism Association criteria for the diagnosis of gout: - A tophus proven to contain urate crystals by chemical or polarized light microscopic means, and/or - Characteristic urate crystals in the joint fluid, and/or - History of at least 6 of the following clinical, laboratory, and x-ray phenomena: - More than 1 attack of acute arthritis - Maximum inflammation developed within 1 day - Monoarticular arthritis - Redness observed over joints - First metatarsophalangeal joint painful or swollen - Unilateral first metatarsophalangeal joint attack - Unilateral tarsal joint attack - Tophus (proven or suspected) - Hyperuricemia - Asymmetric swelling within a joint on x-ray - Subcortical cysts without erosions on x-ray - Joint fluid culture negative for organisms during attack - Must have either: - a serum urate level greater than or equal to 7.0 mg/dL at the Day -7 Visit OR - a serum urate level greater than or equal to 6.0 mg/dL at the Day -7 Visit AND inadequately controlled gout Exclusion Criteria: - Has secondary hyperuricemia - Has a history of xanthinuria - Has received urate-lowering or excluded medication during the screening period - Has a known hypersensitivity to febuxostat or allopurinol or any components of their formulation - Has active peptic ulcer disease - Has a history of cancer within 5 years prior to the first dose of study medication - Had a myocardial infarction or stroke within 60 days prior to the Screening Visit - Has alanine aminotransferase and/or aspartate aminotransferase values greater than 2 times the upper limit of normal during the Screening period - Has a history of drug abuse or a history of alcohol abuse within 5 years prior to the Screening Visit or the subject consumes more than14 alcoholic beverages per week - Has received any investigational medicinal product within the 30 days prior to the Screening Visit and throughout the study - Has an estimated creatinine clearance less than 30 mL/min - Is required to take excluded medications - Has a known history of infection with hepatitis B, hepatitis C, or human immunodeficiency virus
Old
Inclusion Criteria: 1. The subject or the subject's legally acceptable representative signs and dates a written, informed consent form/Health Insurance Portability and Accountability Act (HIPAA) Authorization prior to the initiation of any study procedures. 2. The subject is male ≥50 years of age or female ≥55 years of age and at least 2-years post-menopausal. 3. The subject has a history of major CV or cerebrovascular disease including at least one of the following: - MI. - Hospitalized unstable angina. - Cardiac or cerebrovascular revascularization procedure. - Stroke. - Hospitalized TIA. - Peripheral vascular disease (ankle brachial index ≤0.6, revascularization and/or well-documented history of claudication). - History of diabetes mellitus with evidence of micro- or macrovascular disease (retinopathy, neuropathy, nephropathy, small vessel vascular diseases). 4. The subject has a history or presence of gout defined as having one or more of the American Rheumatism Association criteria for the diagnosis of gout: - A tophus proven to contain urate crystals by chemical or polarized light microscopic means, and/or - Characteristic urate crystals in the joint fluid, and/or - History of at least 6 of the following clinical, laboratory, and x-ray phenomena: - More than 1 attack of acute arthritis. - Maximum inflammation developed within 1 day. - Monoarticular arthritis. - Redness observed over joints. - First metatarsophalangeal joint painful or swollen. - Unilateral first metatarsophalangeal joint attack. - Unilateral tarsal joint attack. - Tophus (proven or suspected). - Hyperuricemia. - Asymmetric swelling within a joint on x-ray. - Subcortical cysts without erosions on x-ray. - Joint fluid culture negative for organisms during attack. 5. The subjects must have either: - a sUA level ≥7.0 mg/dL (≥416 μmol/L) at the Day -7 Visit OR - a sUA level ≥6.0 mg/dL (≥354 μmol/L) at the Day -7 Visit AND inadequately controlled gout (≥1 flare in the 12 months prior to screening and/or the presence of tophi). 6. The subject is capable of understanding and complying with protocol requirements Exclusion Criteria: Subjects who meet any of the following criteria will not qualify for entry into this study: 1. The subject has secondary hyperuricemia (eg, due to myeloproliferative disorder, or organ transplant). 2. The subject has a history of xanthinuria. 3. The subject has received urate-lowering therapy (i.e., febuxostat, allopurinol, probenecid, etc.) or excluded medication during the screening period (beginning with Day -7). 4. The subject has a known hypersensitivity to febuxostat or allopurinol or any components of their formulation. 5. The subject has active peptic ulcer disease. 6. The subject has a history of cancer (other than basal cell carcinoma of the skin) within 5 years prior to the first dose of study medication. 7. The subject had MI or stroke within 60 days prior to the Screening Visit. 8. The subject has ALT and/or AST values greater than 2 times the upper limit of normal (×ULN) during the Screening period. 9. The subject has a significant medical condition and/or conditions that would interfere with the treatment, safety, or compliance with the protocol. 10. The subject has a history of drug abuse (defined as any illicit drug use) or a history of alcohol abuse within 5 years prior to the Screening Visit or the subject consumes >14 alcoholic beverages per week. 11. The subject has received any investigational medicinal product within the 30 days prior to the Screening Visit and throughout the study. 12. The subject's estimated CLcr is <30 mL/min, where CLcr is calculated using the Cockcroft and Gault formula based on ideal body weight (IBW), 13. The subject is an immediate family member, study site employee, or is in a dependant relationship with a study site employee who is involved in conduct of this study (eg, spouse, parent, child, sibling) or may consent under duress. 14. The subject is required to take excluded medications 15. The subject has a known history of infection with hepatitis B, hepatitis C, or human immunodeficiency virus. Inclusion Criteria: - Has a history of major cardiovascular or cerebrovascular disease including at least one of the following: - Myocardial infarction - Hospitalized unstable angina - Cardiac or cerebrovascular revascularization procedure - Stroke - Hospitalized for transient ischemic attack - Peripheral vascular disease - History of diabetes mellitus with evidence of micro- or macrovascular disease - Has a history or presence of gout defined as having one or more of the American Rheumatism Association criteria for the diagnosis of gout: - A tophus proven to contain urate crystals by chemical or polarized light microscopic means, and/or - Characteristic urate crystals in the joint fluid, and/or - History of at least 6 of the following clinical, laboratory, and x-ray phenomena: - More than 1 attack of acute arthritis - Maximum inflammation developed within 1 day - Monoarticular arthritis - Redness observed over joints - First metatarsophalangeal joint painful or swollen - Unilateral first metatarsophalangeal joint attack - Unilateral tarsal joint attack - Tophus (proven or suspected) - Hyperuricemia - Asymmetric swelling within a joint on x-ray - Subcortical cysts without erosions on x-ray - Joint fluid culture negative for organisms during attack - Must have either: - a serum urate level greater than or equal to 7.0 mg/dL at the Day -7 Visit OR - a serum urate level greater than or equal to 6.0 mg/dL at the Day -7 Visit AND inadequately controlled gout Exclusion Criteria: - Has secondary hyperuricemia - Has a history of xanthinuria - Has received urate-lowering or excluded medication during the screening period - Has a known hypersensitivity to febuxostat or allopurinol or any components of their formulation - Has active peptic ulcer disease - Has a history of cancer within 5 years prior to the first dose of study medication - Had a myocardial infarction or stroke within 60 days prior to the Screening Visit - Has alanine aminotransferase and/or aspartate aminotransferase values greater than 2 times the upper limit of normal during the Screening period - Has a history of drug abuse or a history of alcohol abuse within 5 years prior to the Screening Visit or the subject consumes more than14 alcoholic beverages per week - Has received any investigational medicinal product within the 30 days prior to the Screening Visit and throughout the study - Has an estimated creatinine clearance less than 30 mL/min - Is required to take excluded medications - Has a known history of infection with hepatitis B, hepatitis C, or human immunodeficiency virus
A location was updated in Birmingham.
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The overall status was removed for Name Unavailable.
A location was updated in Birmingham.
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The overall status was removed for Name Unavailable.
A location was updated in Mesa.
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The overall status was removed for Name Unavailable.
A location was updated in Mesa.
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A location was updated in Tucson.
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A location was updated in Little Rock.
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A location was updated in Little Rock.
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A location was updated in Los Angeles.
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A location was updated in Los Angeles.
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A location was updated in Roseville.
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A location was updated in Sacramento.
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The overall status was removed for Name Unavailable.
A location was updated in Sacramento.
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The overall status was removed for Name Unavailable.
A location was updated in Tustin.
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The overall status was removed for Name Unavailable.
A location was updated in Tustin.
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A location was updated in Wheat Ridge.
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The overall status was removed for Name Unavailable.
A location was updated in Miami.
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The overall status was removed for Name Unavailable.
A location was updated in Miami.
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A location was updated in St Petersburg.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in St Petersburg.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Tampa.
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The overall status was removed for Name Unavailable.
A location was updated in Tampa.
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The overall status was removed for Name Unavailable.
A location was updated in Atlanta.
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The overall status was removed for Name Unavailable.
A location was updated in Atlanta.
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The overall status was removed for Name Unavailable.
A location was updated in Chicago.
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The overall status was removed for Name Unavailable.
A location was updated in Chicago.
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The overall status was removed for Name Unavailable.
A location was updated in Springfield.
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The overall status was removed for Name Unavailable.
A location was updated in Springfield.
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A location was updated in Baltimore.
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The overall status was removed for Name Unavailable.
A location was updated in Baltimore.
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The overall status was removed for Name Unavailable.
A location was updated in Ann Arbor.
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The overall status was removed for Name Unavailable.
A location was updated in Ann Arbor.
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The overall status was removed for Name Unavailable.
A location was updated in Detroit.
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The overall status was removed for Name Unavailable.
A location was updated in Detroit.
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The overall status was removed for Name Unavailable.
A location was updated in Edina.
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The overall status was removed for Name Unavailable.
A location was updated in Edina.
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The overall status was removed for Name Unavailable.
A location was updated in Saint Louis.
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The overall status was removed for Name Unavailable.
A location was updated in Saint Louis.
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A location was updated in New York.
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The overall status was removed for Name Unavailable.
A location was updated in New York.
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A location was updated in Wilmington.
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The overall status was removed for Name Unavailable.
A location was updated in Wilmington.
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A location was updated in Dayton.
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The overall status was removed for Name Unavailable.
A location was updated in Dayton.
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The overall status was removed for Name Unavailable.
A location was updated in Toledo.
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The overall status was removed for Name Unavailable.
A location was updated in Toledo.
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A location was updated in Willoughby Hills.
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A location was updated in Willoughby Hills.
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A location was updated in Charleston.
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The overall status was removed for Name Unavailable.
A location was updated in Charleston.
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The overall status was removed for Name Unavailable.
A location was updated in Chattanooga.
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The overall status was removed for Name Unavailable.
A location was updated in Chattanooga.
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The overall status was removed for Name Unavailable.
A location was updated in Memphis.
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The overall status was removed for Name Unavailable.
A location was updated in Memphis.
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The overall status was removed for Name Unavailable.
A location was updated in Dallas.
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The overall status was removed for Name Unavailable.
A location was updated in Dallas.
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The overall status was removed for Name Unavailable.
A location was updated in Houston.
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The overall status was removed for Name Unavailable.
A location was updated in Houston.
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A location was updated in San Antonio.
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The overall status was removed for Name Unavailable.
A location was updated in San Antonio.
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The overall status was removed for Name Unavailable.
A location was updated in Sugar Land.
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The overall status was removed for Name Unavailable.
A location was updated in Sugar Land.
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The overall status was removed for Name Unavailable.
A location was updated in Salt Lake City.
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The overall status was removed for Name Unavailable.
A location was updated in Salt Lake City.
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The overall status was removed for Name Unavailable.
A location was updated in Brampton.
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The overall status was removed for Name Unavailable.
A location was updated in Brampton.
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The overall status was removed for Name Unavailable.
A location was updated in Ciudad De México.
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The overall status was removed for Name Unavailable.
A location was updated in Guadalajara.
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The overall status was removed for Name Unavailable.
A location was updated in Guadalajara.
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The overall status was removed for Name Unavailable.
14 Aug '15
A location was updated in Birmingham.
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The overall status was removed for Name Unavailable.
A location was updated in Columbiana.
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The overall status was removed for Name Unavailable.
A location was updated in Ozark.
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The overall status was removed for Name Unavailable.
A location was updated in Goodyear.
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The overall status was removed for Name Unavailable.
A location was updated in Mesa.
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The overall status was removed for Name Unavailable.
A location was updated in Tucson.
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The overall status was removed for Name Unavailable.
A location was updated in Tucson.
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The overall status was removed for Name Unavailable.
A location was updated in Little Rock.
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The overall status was removed for Name Unavailable.
A location was updated in Buena Park.
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The overall status was removed for Name Unavailable.
A location was updated in Carlsbad.
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A location was updated in Huntington Park.
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The overall status was removed for Name Unavailable.
A location was updated in Lancaster.
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The overall status was removed for Name Unavailable.
A location was updated in Los Angeles.
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A location was updated in Roseville.
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The overall status was removed for Name Unavailable.
A location was updated in Roseville.
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The overall status was removed for Name Unavailable.
A location was updated in Sacramento.
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The overall status was removed for Name Unavailable.
A location was updated in Tustin.
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The overall status was removed for Name Unavailable.
A location was updated in Vista.
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The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
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The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
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A location was updated in Stamford.
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A location was updated in Fort Lauderdale.
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A location was updated in Hialeah.
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The overall status was removed for Name Unavailable.
A location was updated in Miami.
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The overall status was removed for Name Unavailable.
A location was updated in St Petersburg.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in St Petersburg.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Summerfield.
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The overall status was removed for Name Unavailable.
A location was updated in Tampa.
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The overall status was removed for Name Unavailable.
A location was updated in Atlanta.
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The overall status was removed for Name Unavailable.
A location was updated in Boise.
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A location was updated in Nampa.
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A location was updated in Chicago.
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A location was updated in Evergreen Park.
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A location was updated in Melrose Park.
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A location was updated in Naperville.
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A location was updated in Springfield.
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The overall status was removed for Name Unavailable.
A location was updated in Monroe.
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The overall status was removed for Name Unavailable.
A location was updated in Baltimore.
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The overall status was removed for Name Unavailable.
A location was updated in Ann Arbor.
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The overall status was removed for Name Unavailable.
A location was updated in Detroit.
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The overall status was removed for Name Unavailable.
A location was updated in Edina.
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The overall status was removed for Name Unavailable.
A location was updated in Saint Louis.
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A location was updated in Brick.
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A location was updated in Edison.
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A location was updated in Freeport.
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The overall status was removed for Name Unavailable.
A location was updated in New York.
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A location was updated in Wilmington.
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The overall status was removed for Name Unavailable.
A location was updated in Dayton.
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The overall status was removed for Name Unavailable.
A location was updated in Toledo.
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A location was updated in Willoughby Hills.
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A location was updated in Altoona.
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A location was updated in Bensalem.
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A location was updated in Downingtown.
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A location was updated in Ephrata.
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A location was updated in Quakertown.
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A location was updated in Anderson.
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A location was updated in Charleston.
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A location was updated in Chattanooga.
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A location was updated in Kingsport.
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A location was updated in Memphis.
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The overall status was removed for Name Unavailable.
A location was updated in Dallas.
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A location was updated in Grapevine.
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A location was updated in Houston.
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A location was updated in Odessa.
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A location was updated in Richardson.
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A location was updated in San Antonio.
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A location was updated in Southlake.
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A location was updated in Sugar Land.
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A location was updated in Salt Lake City.
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A location was updated in Clarksburg.
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A location was updated in Brampton.
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The overall status was removed for Name Unavailable.
A location was updated in Quebec.
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The overall status was removed for Name Unavailable.
A location was updated in Mexico.
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The overall status was removed for Name Unavailable.
A location was updated in Ciudad De México.
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The overall status was removed for Name Unavailable.
A location was updated in Celaya.
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A location was updated in Guadalajara.
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The overall status was removed for Name Unavailable.
24 Jul '14
A location was updated in Mobile.
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The overall status was removed for Name Unavailable.
A location was updated in Mobile.
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The overall status was removed for Name Unavailable.
A location was updated in Anaheim.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Anaheim.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Buena Park.
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The overall status was removed for Name Unavailable.
A location was updated in Buena Park.
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A location was updated in Carmichael.
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A location was updated in Carmichael.
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A location was updated in Citrus Heights.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Citrus Heights.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Huntington Park.
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A location was updated in Huntington Park.
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A location was updated in La Jolla.
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A location was updated in La Jolla.
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A location was updated in Riverside.
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A location was updated in Riverside.
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A location was updated in Roseville.
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A location was updated in Roseville.
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A location was updated in San Jose.
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A location was updated in San Jose.
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A location was updated in Vista.
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The overall status was removed for Name Unavailable.
A location was updated in Vista.
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A location was updated in Arvada.
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A location was updated in Arvada.
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A location was updated in Longmont.
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The overall status was removed for Name Unavailable.
A location was updated in Longmont.
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The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
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The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
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The overall status was removed for Name Unavailable.
A location was updated in Milford.
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The overall status was removed for Name Unavailable.
A location was updated in Milford.
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The overall status was removed for Name Unavailable.
A location was updated in Stamford.
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The overall status was removed for Name Unavailable.
A location was updated in Stamford.
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The overall status was removed for Name Unavailable.
A location was updated in Trumbull.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Trumbull.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Boca Raton.
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The overall status was removed for Name Unavailable.
A location was updated in Boca Raton.
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The overall status was removed for Name Unavailable.
A location was updated in Cutler Bay.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Cutler Bay.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Fort Lauderdale.
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The overall status was removed for Name Unavailable.
A location was updated in Fort Lauderdale.
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The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
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The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
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The overall status was removed for Name Unavailable.
A location was updated in New Smyrna Beach.
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The overall status was removed for Name Unavailable.
A location was updated in New Smyrna Beach.
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The overall status was removed for Name Unavailable.
A location was updated in Pinellas Park.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Pinellas Park.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in St Petersburg.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in St Petersburg.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Tamarac.
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The overall status was removed for Name Unavailable.
A location was updated in Tamarac.
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The overall status was removed for Name Unavailable.
A location was updated in West Palm Beach.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in West Palm Beach.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Decatur.
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The overall status was removed for Name Unavailable.
A location was updated in Decatur.
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The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
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The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
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A location was updated in Evanston.
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The overall status was removed for Name Unavailable.
A location was updated in Evanston.
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The overall status was removed for Name Unavailable.
A location was updated in Evergreen Park.
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The overall status was removed for Name Unavailable.
A location was updated in Evergreen Park.
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The overall status was removed for Name Unavailable.
A location was updated in Maywood.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Maywood.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Naperville.
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The overall status was removed for Name Unavailable.
A location was updated in Naperville.
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The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
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The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
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The overall status was removed for Name Unavailable.
A location was updated in Lafayette.
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The overall status was removed for Name Unavailable.
A location was updated in Lafayette.
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The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
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The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
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The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
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The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
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The overall status was removed for Name Unavailable.
A location was updated in Monroe.
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The overall status was removed for Name Unavailable.
A location was updated in Monroe.
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The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
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The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
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The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
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The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
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The overall status was removed for Name Unavailable.
A location was updated in Brooklyn Center.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Brooklyn Center.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Chaska.
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The overall status was removed for Name Unavailable.
A location was updated in Chaska.
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The overall status was removed for Name Unavailable.
A location was updated in Duluth.
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The overall status was removed for Name Unavailable.
A location was updated in Duluth.
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The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
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The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
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The overall status was removed for Name Unavailable.
A location was updated in Lumberton.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Lumberton.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Poughkeepsie.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Poughkeepsie.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Huntersville.
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The overall status was removed for Name Unavailable.
A location was updated in Huntersville.
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The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
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The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
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The overall status was removed for Name Unavailable.
A location was updated in Cranston.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cranston.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cumberland.
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The overall status was removed for Name Unavailable.
A location was updated in Cumberland.
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The overall status was removed for Name Unavailable.
A location was updated in East Providence.
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The overall status was removed for Name Unavailable.
A location was updated in East Providence.
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The overall status was removed for Name Unavailable.
A location was updated in Anderson.
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The overall status was removed for Name Unavailable.
A location was updated in Anderson.
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The overall status was removed for Name Unavailable.
A location was updated in Murrells Inlet.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Murrells Inlet.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Allen.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Allen.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in DeSoto.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in DeSoto.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Southlake.
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The overall status was removed for Name Unavailable.
A location was updated in Southlake.
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The overall status was removed for Name Unavailable.
A location was updated in Waco.
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The overall status was removed for Name Unavailable.
A location was updated in Waco.
New
The overall status was removed for Name Unavailable.
A location was updated in Burke.
New
The overall status was removed for Name Unavailable.
A location was updated in Burke.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
28 Jun '14
A location was updated in Mobile.
New
The overall status was removed for Name Unavailable.
A location was updated in Mobile.
New
The overall status was removed for Name Unavailable.
A location was updated in North Alabaster.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Anaheim.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Anaheim.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Buena Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Buena Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Carmichael.
New
The overall status was removed for Name Unavailable.
A location was updated in Carmichael.
New
The overall status was removed for Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Huntington Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Huntington Park.
New
The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
New
The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
New
The overall status was removed for Name Unavailable.
A location was updated in Riverside.
New
The overall status was removed for Name Unavailable.
A location was updated in Roseville.
New
The overall status was removed for Name Unavailable.
A location was updated in Roseville.
New
The overall status was removed for Name Unavailable.
A location was updated in San Jose.
New
The overall status was removed for Name Unavailable.
A location was updated in Vista.
New
The overall status was removed for Name Unavailable.
A location was updated in Vista.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Longmont.
New
The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
New
The overall status was removed for Name Unavailable.
A location was updated in Milford.
New
The overall status was removed for Name Unavailable.
A location was updated in Milford.
New
The overall status was removed for Name Unavailable.
A location was updated in Stamford.
New
The overall status was removed for Name Unavailable.
A location was updated in Stamford.
New
The overall status was removed for Name Unavailable.
A location was updated in Trumbull.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Boca Raton.
New
The overall status was removed for Name Unavailable.
A location was updated in Boca Raton.
New
The overall status was removed for Name Unavailable.
A location was updated in Cutler Bay.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Cutler Bay.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Fort Lauderdale.
New
The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
New
The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
New
The overall status was removed for Name Unavailable.
A location was updated in New Smyrna Beach.
New
The overall status was removed for Name Unavailable.
A location was updated in New Smyrna Beach.
New
The overall status was removed for Name Unavailable.
A location was updated in Pinellas Park.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in St Petersburg.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
New
The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
New
The overall status was removed for Name Unavailable.
A location was updated in Evanston.
New
The overall status was removed for Name Unavailable.
A location was updated in Evergreen Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Evergreen Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Maywood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Naperville.
New
The overall status was removed for Name Unavailable.
A location was updated in Naperville.
New
The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
New
The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
New
The overall status was removed for Name Unavailable.
A location was updated in Lafayette.
New
The overall status was removed for Name Unavailable.
A location was updated in Lafayette.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Monroe.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Chaska.
New
The overall status was removed for Name Unavailable.
A location was updated in Chaska.
New
The overall status was removed for Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Lumberton.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Huntersville.
New
The overall status was removed for Name Unavailable.
A location was updated in Huntersville.
New
The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
New
The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
New
The overall status was removed for Name Unavailable.
A location was updated in Cranston.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in East Providence.
New
The overall status was removed for Name Unavailable.
A location was updated in Anderson.
New
The overall status was removed for Name Unavailable.
A location was updated in Anderson.
New
The overall status was removed for Name Unavailable.
A location was updated in Murrells Inlet.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Murrells Inlet.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Allen.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Allen.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in DeSoto.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Southlake.
New
The overall status was removed for Name Unavailable.
A location was updated in Southlake.
New
The overall status was removed for Name Unavailable.
A location was updated in Waco.
New
The overall status was removed for Name Unavailable.
A location was updated in Waco.
New
The overall status was removed for Name Unavailable.
A location was updated in Burke.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
29 May '14
A location was updated in Mobile.
New
The overall status was removed for Name Unavailable.
A location was updated in Mobile.
New
The overall status was removed for Name Unavailable.
A location was updated in Anaheim.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Buena Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Carmichael.
New
The overall status was removed for Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Huntington Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Huntington Park.
New
The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
New
The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
New
The overall status was removed for Name Unavailable.
A location was updated in Riverside.
New
The overall status was removed for Name Unavailable.
A location was updated in San Jose.
New
The overall status was removed for Name Unavailable.
A location was updated in San Jose.
New
The overall status was removed for Name Unavailable.
A location was updated in Vista.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Glenwood Springs.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Longmont.
New
The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
New
The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
New
The overall status was removed for Name Unavailable.
A location was updated in Milford.
New
The overall status was removed for Name Unavailable.
A location was updated in Stamford.
New
The overall status was removed for Name Unavailable.
A location was updated in Trumbull.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Boca Raton.
New
The overall status was removed for Name Unavailable.
A location was updated in Boca Raton.
New
The overall status was removed for Name Unavailable.
A location was updated in Cutler Bay.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Cutler Bay.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Fort Lauderdale.
New
The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
New
The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
New
The overall status was removed for Name Unavailable.
A location was updated in New Smyrna Beach.
New
The overall status was removed for Name Unavailable.
A location was updated in Pinellas Park.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Pinellas Park.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in St Petersburg.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in St Petersburg.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
New
The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
New
The overall status was removed for Name Unavailable.
A location was updated in Evanston.
New
The overall status was removed for Name Unavailable.
A location was updated in Evanston.
New
The overall status was removed for Name Unavailable.
A location was updated in Evergreen Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Evergreen Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Maywood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Maywood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Naperville.
New
The overall status was removed for Name Unavailable.
A location was updated in Naperville.
New
The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
New
The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
New
The overall status was removed for Name Unavailable.
A location was updated in Lafayette.
New
The overall status was removed for Name Unavailable.
A location was updated in Lafayette.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Monroe.
New
The overall status was removed for Name Unavailable.
A location was updated in Monroe.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Baltimore.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Chaska.
New
The overall status was removed for Name Unavailable.
A location was updated in Chaska.
New
The overall status was removed for Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Lumberton.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Lumberton.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Huntersville.
New
The overall status was removed for Name Unavailable.
A location was updated in Huntersville.
New
The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
New
The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
New
The overall status was removed for Name Unavailable.
A location was updated in Cranston.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cranston.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in East Providence.
New
The overall status was removed for Name Unavailable.
A location was updated in East Providence.
New
The overall status was removed for Name Unavailable.
A location was updated in Anderson.
New
The overall status was removed for Name Unavailable.
A location was updated in Anderson.
New
The overall status was removed for Name Unavailable.
A location was updated in Murrells Inlet.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Murrells Inlet.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Allen.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Allen.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in DeSoto.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in DeSoto.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Southlake.
New
The overall status was removed for Name Unavailable.
A location was updated in Southlake.
New
The overall status was removed for Name Unavailable.
A location was updated in Waco.
New
The overall status was removed for Name Unavailable.
A location was updated in Waco.
New
The overall status was removed for Name Unavailable.
A location was updated in Burke.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
15 May '14
A location was updated in Mobile.
New
The overall status was removed for Name Unavailable.
A location was updated in Mobile.
New
The overall status was removed for Name Unavailable.
A location was updated in Anaheim.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Anaheim.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Buena Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Buena Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Carmichael.
New
The overall status was removed for Name Unavailable.
A location was updated in Carmichael.
New
The overall status was removed for Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Huntington Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Huntington Park.
New
The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
New
The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
New
The overall status was removed for Name Unavailable.
A location was updated in Riverside.
New
The overall status was removed for Name Unavailable.
A location was updated in Riverside.
New
The overall status was removed for Name Unavailable.
A location was updated in San Jose.
New
The overall status was removed for Name Unavailable.
A location was updated in San Jose.
New
The overall status was removed for Name Unavailable.
A location was updated in Vista.
New
The overall status was removed for Name Unavailable.
A location was updated in Vista.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Longmont.
New
The overall status was removed for Name Unavailable.
A location was updated in Longmont.
New
The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
New
The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
New
The overall status was removed for Name Unavailable.
A location was updated in Milford.
New
The overall status was removed for Name Unavailable.
A location was updated in Milford.
New
The overall status was removed for Name Unavailable.
A location was updated in Stamford.
New
The overall status was removed for Name Unavailable.
A location was updated in Stamford.
New
The overall status was removed for Name Unavailable.
A location was updated in Trumbull.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Trumbull.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cutler Bay.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Cutler Bay.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Fort Lauderdale.
New
The overall status was removed for Name Unavailable.
A location was updated in Fort Lauderdale.
New
The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
New
The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
New
The overall status was removed for Name Unavailable.
A location was updated in Pinellas Park.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Pinellas Park.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in St Petersburg.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in St Petersburg.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
New
The overall status was removed for Name Unavailable.
A location was updated in Evanston.
New
The overall status was removed for Name Unavailable.
A location was updated in Evanston.
New
The overall status was removed for Name Unavailable.
A location was updated in Evergreen Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Evergreen Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Maywood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Maywood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Naperville.
New
The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
New
The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
New
The overall status was removed for Name Unavailable.
A location was updated in Lafayette.
New
The overall status was removed for Name Unavailable.
A location was updated in Lafayette.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Monroe.
New
The overall status was removed for Name Unavailable.
A location was updated in Monroe.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Baltimore.
New
The overall status was removed for Name Unavailable.
A location was updated in Baltimore.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Chaska.
New
The overall status was removed for Name Unavailable.
A location was updated in Chaska.
New
The overall status was removed for Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Lumberton.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Lumberton.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Huntersville.
New
The overall status was removed for Name Unavailable.
A location was updated in Huntersville.
New
The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
New
The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
New
The overall status was removed for Name Unavailable.
A location was updated in Cranston.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cranston.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in East Providence.
New
The overall status was removed for Name Unavailable.
A location was updated in East Providence.
New
The overall status was removed for Name Unavailable.
A location was updated in Anderson.
New
The overall status was removed for Name Unavailable.
A location was updated in Anderson.
New
The overall status was removed for Name Unavailable.
A location was updated in Murrells Inlet.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Murrells Inlet.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Allen.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Allen.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in DeSoto.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in DeSoto.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Southlake.
New
The overall status was removed for Name Unavailable.
A location was updated in Southlake.
New
The overall status was removed for Name Unavailable.
A location was updated in Waco.
New
The overall status was removed for Name Unavailable.
A location was updated in Waco.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
27 Mar '14
A location was updated in Mobile.
New
The overall status was removed for Name Unavailable.
A location was updated in Mobile.
New
The overall status was removed for Name Unavailable.
A location was updated in North Alabaster.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Anaheim.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Buena Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Carmichael.
New
The overall status was removed for Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Huntington Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Huntington Park.
New
The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
New
The overall status was removed for Name Unavailable.
A location was updated in Modesto.
New
The overall status was removed for Name Unavailable.
A location was updated in Riverside.
New
The overall status was removed for Name Unavailable.
A location was updated in Riverside.
New
The overall status was removed for Name Unavailable.
A location was updated in San Jose.
New
The overall status was removed for Name Unavailable.
A location was updated in San Jose.
New
The overall status was removed for Name Unavailable.
A location was updated in Vista.
New
The overall status was removed for Name Unavailable.
A location was updated in Vista.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Longmont.
New
The overall status was removed for Name Unavailable.
A location was updated in Longmont.
New
The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
New
The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
New
The overall status was removed for Name Unavailable.
A location was updated in Milford.
New
The overall status was removed for Name Unavailable.
A location was updated in Milford.
New
The overall status was removed for Name Unavailable.
A location was updated in Stamford.
New
The overall status was removed for Name Unavailable.
A location was updated in Stamford.
New
The overall status was removed for Name Unavailable.
A location was updated in Trumbull.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Trumbull.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cutler Bay.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Cutler Bay.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Fort Lauderdale.
New
The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
New
The overall status was removed for Name Unavailable.
A location was updated in Pinellas Park.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in St Petersburg.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
New
The overall status was removed for Name Unavailable.
A location was updated in Evanston.
New
The overall status was removed for Name Unavailable.
A location was updated in Evanston.
New
The overall status was removed for Name Unavailable.
A location was updated in Maywood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Naperville.
New
The overall status was removed for Name Unavailable.
A location was updated in Naperville.
New
The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
New
The overall status was removed for Name Unavailable.
A location was updated in Lafayette.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Monroe.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Baltimore.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Chaska.
New
The overall status was removed for Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Lumberton.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Lumberton.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Huntersville.
New
The overall status was removed for Name Unavailable.
A location was updated in Huntersville.
New
The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
New
The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
New
The overall status was removed for Name Unavailable.
A location was updated in Cranston.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cranston.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in East Providence.
New
The overall status was removed for Name Unavailable.
A location was updated in East Providence.
New
The overall status was removed for Name Unavailable.
A location was updated in Anderson.
New
The overall status was removed for Name Unavailable.
A location was updated in Anderson.
New
The overall status was removed for Name Unavailable.
A location was updated in Murrells Inlet.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Murrells Inlet.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Allen.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Allen.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in DeSoto.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in DeSoto.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Southlake.
New
The overall status was removed for Name Unavailable.
A location was updated in Southlake.
New
The overall status was removed for Name Unavailable.
A location was updated in Waco.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
7 Feb '14
A location was updated in Mobile.
New
The overall status was removed for Name Unavailable.
A location was updated in Anaheim.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Buena Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Buena Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Carmichael.
New
The overall status was removed for Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Huntington Park.
New
The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
New
The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
New
The overall status was removed for Name Unavailable.
A location was updated in Lakewood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Modesto.
New
The overall status was removed for Name Unavailable.
A location was updated in Riverside.
New
The overall status was removed for Name Unavailable.
A location was updated in San Jose.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Glenwood Springs.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Longmont.
New
The overall status was removed for Name Unavailable.
A location was updated in Longmont.
New
The overall status was removed for Name Unavailable.
A location was updated in Wheat Ridge.
New
The overall status was removed for Name Unavailable.
A location was updated in Milford.
New
The overall status was removed for Name Unavailable.
A location was updated in Milford.
New
The overall status was removed for Name Unavailable.
A location was updated in Stamford.
New
The overall status was removed for Name Unavailable.
A location was updated in Trumbull.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Trumbull.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cutler Bay.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Fort Lauderdale.
New
The overall status was removed for Name Unavailable.
A location was updated in Fort Lauderdale.
New
The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
New
The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
New
The overall status was removed for Name Unavailable.
A location was updated in Pinellas Park.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Pinellas Park.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in St Petersburg.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in St Petersburg.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
New
The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
New
The overall status was removed for Name Unavailable.
A location was updated in Evanston.
New
The overall status was removed for Name Unavailable.
A location was updated in Maywood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Maywood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Naperville.
New
The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Monroe.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Lumberton.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Lumberton.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Huntersville.
New
The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
New
The overall status was removed for Name Unavailable.
A location was updated in Willoughby Hills.
New
The overall status was removed for Name Unavailable.
A location was updated in Cranston.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cranston.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in East Providence.
New
The overall status was removed for Name Unavailable.
A location was updated in East Providence.
New
The overall status was removed for Name Unavailable.
A location was updated in Anderson.
New
The overall status was removed for Name Unavailable.
A location was updated in Anderson.
New
The overall status was removed for Name Unavailable.
A location was updated in Murrells Inlet.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Allen.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in DeSoto.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in DeSoto.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Fort Worth.
New
The overall status was removed for Name Unavailable.
A location was updated in Fort Worth.
New
The overall status was removed for Name Unavailable.
A location was updated in Southlake.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
A location was updated in Weston.
New
The overall status was removed for Name Unavailable.
A location was updated in Mexicali.
New
The overall status was removed for Name Unavailable.
A location was updated in Zapopan.
New
The overall status was removed for Name Unavailable.
A location was updated in Cuernavaca.
New
The overall status was removed for Name Unavailable.
A location was updated in Aguascalientes.
New
The overall status was removed for Name Unavailable.
14 Nov '13
A location was updated in Mobile.
New
The overall status was removed for Name Unavailable.
A location was updated in Mobile.
New
The overall status was removed for Name Unavailable.
A location was updated in Carmichael.
New
The overall status was removed for Name Unavailable.
A location was updated in Carmichael.
New
The overall status was removed for Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Citrus Heights.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Huntington Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Huntington Park.
New
The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
New
The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
New
The overall status was removed for Name Unavailable.
A location was updated in Lakewood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Lakewood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in San Jose.
New
The overall status was removed for Name Unavailable.
A location was updated in San Jose.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Arvada.
New
The overall status was removed for Name Unavailable.
A location was updated in Longmont.
New
The overall status was removed for Name Unavailable.
A location was updated in Longmont.
New
The overall status was removed for Name Unavailable.
A location was updated in Milford.
New
The overall status was removed for Name Unavailable.
A location was updated in Milford.
New
The overall status was removed for Name Unavailable.
A location was updated in Stamford.
New
The overall status was removed for Name Unavailable.
A location was updated in Stamford.
New
The overall status was removed for Name Unavailable.
A location was updated in Trumbull.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Trumbull.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cutler Bay.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Cutler Bay.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Fort Lauderdale.
New
The overall status was removed for Name Unavailable.
A location was updated in Fort Lauderdale.
New
The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
New
The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
New
The overall status was removed for Name Unavailable.
A location was updated in Pinellas Park.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Pinellas Park.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in St Petersburg.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in St Petersburg.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Summerfield.
New
The overall status was removed for Name Unavailable.
A location was updated in Summerfield.
New
The overall status was removed for Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in Tamarac.
New
The overall status was removed for Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in West Palm Beach.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Decatur.
New
The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
New
The overall status was removed for Name Unavailable.
A location was updated in Arlington Heights.
New
The overall status was removed for Name Unavailable.
A location was updated in Evanston.
New
The overall status was removed for Name Unavailable.
A location was updated in Evanston.
New
The overall status was removed for Name Unavailable.
A location was updated in Maywood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Maywood.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Naperville.
New
The overall status was removed for Name Unavailable.
A location was updated in Naperville.
New
The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
New
The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
New
The overall status was removed for Name Unavailable.
A location was updated in Monroe.
New
The overall status was removed for Name Unavailable.
A location was updated in Monroe.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Hyannis.
New
The overall status was removed for Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Brooklyn Center.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Duluth.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
New
The overall status was removed for Name Unavailable.
A location was updated in Lumberton.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Lumberton.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Poughkeepsie.
New
The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Cranston.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cranston.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in Cumberland.
New
The overall status was removed for Name Unavailable.
A location was updated in East Providence.
New
The overall status was removed for Name Unavailable.
A location was updated in East Providence.
New
The overall status was removed for Name Unavailable.
A location was updated in Murrells Inlet.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Murrells Inlet.
New
The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in DeSoto.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in DeSoto.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Fort Worth.
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The overall status was removed for Name Unavailable.
A location was updated in Fort Worth.
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The overall status was removed for Name Unavailable.
A location was updated in Southlake.
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The overall status was removed for Name Unavailable.
A location was updated in Southlake.
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The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
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The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
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The overall status was removed for Name Unavailable.
A location was updated in Weston.
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The overall status was removed for Name Unavailable.
A location was updated in Weston.
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The overall status was removed for Name Unavailable.
2 Nov '13
A location was updated in Mobile.
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The overall status was removed for Name Unavailable.
A location was updated in Mobile.
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The overall status was removed for Name Unavailable.
A location was updated in Green Valley.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Peoria.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Carmichael.
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The overall status was removed for Name Unavailable.
A location was updated in Carmichael.
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The overall status was removed for Name Unavailable.
A location was updated in Citrus Heights.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Citrus Heights.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Huntington Park.
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The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
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The overall status was removed for Name Unavailable.
A location was updated in La Jolla.
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The overall status was removed for Name Unavailable.
A location was updated in Lakewood.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in San Jose.
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The overall status was removed for Name Unavailable.
A location was updated in Arvada.
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The overall status was removed for Name Unavailable.
A location was updated in Longmont.
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The overall status was removed for Name Unavailable.
A location was updated in Milford.
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The overall status was removed for Name Unavailable.
A location was updated in Milford.
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The overall status was removed for Name Unavailable.
A location was updated in Stamford.
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The overall status was removed for Name Unavailable.
A location was updated in Stamford.
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The overall status was removed for Name Unavailable.
A location was updated in Trumbull.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Trumbull.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Aventura.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Cutler Bay.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Cutler Bay.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Fort Lauderdale.
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The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
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The overall status was removed for Name Unavailable.
A location was updated in Hollywood.
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The overall status was removed for Name Unavailable.
A location was updated in Pinellas Park.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Pinellas Park.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in St Petersburg.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Summerfield.
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The overall status was removed for Name Unavailable.
A location was updated in Summerfield.
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The overall status was removed for Name Unavailable.
A location was updated in Tamarac.
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The overall status was removed for Name Unavailable.
A location was updated in West Palm Beach.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Decatur.
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The overall status was removed for Name Unavailable.
A location was updated in Gainesville.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Arlington Heights.
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The overall status was removed for Name Unavailable.
A location was updated in Evanston.
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The overall status was removed for Name Unavailable.
A location was updated in Maywood.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Maywood.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Naperville.
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The overall status was removed for Name Unavailable.
A location was updated in Naperville.
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The overall status was removed for Name Unavailable.
A location was updated in Bloomington.
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The overall status was removed for Name Unavailable.
A location was updated in Overland Park.
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The overall status was removed for Name Unavailable.
A location was updated in Mer Rouge.
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The overall status was removed for Name Unavailable.
A location was updated in Monroe.
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The overall status was removed for Name Unavailable.
A location was updated in Shreveport.
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The overall status was removed for Name Unavailable.
A location was updated in Rockville.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Hyannis.
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The overall status was removed for Name Unavailable.
A location was updated in Brooklyn Center.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Duluth.
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The overall status was removed for Name Unavailable.
A location was updated in Clarkson Valley.
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The overall status was removed for Name Unavailable.
A location was updated in Lumberton.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Medford.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Poughkeepsie.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Norman.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Cranston.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Cumberland.
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The overall status was removed for Name Unavailable.
A location was updated in East Providence.
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The overall status was removed for Name Unavailable.
A location was updated in East Providence.
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The overall status was removed for Name Unavailable.
A location was updated in Murrells Inlet.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Germantown.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in DeSoto.
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The overall status was updated to "Recruiting" at Name Unavailable.
A location was updated in Fort Worth.
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The overall status was removed for Name Unavailable.
A location was updated in Fort Worth.
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The overall status was removed for Name Unavailable.
A location was updated in Mesquite.
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The overall status was updated to "Completed" at Name Unavailable.
A location was updated in Southlake.
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The overall status was removed for Name Unavailable.
A location was updated in Tacoma.
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The overall status was removed for Name Unavailable.
A location was updated in Weston.
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The overall status was removed for Name Unavailable.
26 Sep '13
The Summary of Purpose was updated.
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The purpose of this study is to see whether subjects with gout who receive febuxostat or allopurinol for up to 9 years have a higher rate of serious heart and blood vessel complications (major cardiovascular events). Examples of major cardiovascular events include heart attacks, strokes, and angina (chest pain due to narrowing of the blood vessels of the heart) that need to be treated urgently with a heart operation. The overall duration of the study is dependent on the number of predefined major cardiovascular events (MACE). The length of study is expected to be approximately 9 years in order to observe the required 624 MACE. The length of study participation for each subject will vary due to the event driven study design. The purpose of this study is to see if subjects with gout who receive febuxostat or allopurinol, once daily (QD), have a higher rate of serious heart and blood vessel complications.
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The purpose of this study is to see if subjects with gout who receive febuxostat or allopurinol, once daily (QD), have a higher rate of serious heart and blood vessel complications.
The description was updated.
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This is a phase 3B multicenter, randomized, double-blind, active-controlled study designed to evaluate the cardiovascular (CV) safety of febuxostat compared with allopurinol in subjects with gout and significant CV comorbidities. Approximately 7500 subjects, males 50 years of age or older or females 55 years of age or older (at least 2-years post-menopausal), with gout and health problems affecting the heart or blood vessels will take part in this study at approximately 450 study centers in North America. This study will use competitive enrollment. This means that when a target number of subjects has entered the treatment phase of the study, all further screening of subjects will be closed. The length of the study is based on an ongoing review of study results. The participation will last a maximum of 9 years and will include a maximum 28 visits to the study center. Telephone contact will be made every 2 months for subjects who have discontinued the study drug for any reason, but who are asked to continue in the study to be followed for potential cardiovascular events. This study design is called a "Time to Event Study". All study subjects will continue to be followed until enough information has been gathered to determine the overall safety of the study drug. Gout is caused by high levels of uric acid in the body, and is associated with a broad range of conditions including heart disease, chronic kidney disease and additional risk factors like obesity and high blood pressure. Hyperuricemia, which is defined as an elevation in serum urate levels, develops into gout when urate crystals form from supersaturated body fluids and settle in joints and other organs. People with gout may also have a higher incidence of other conditions that may be associated with hyperuricemia, gout or both. This is supported by a growing body of research demonstrating that serum urate levels are an independent predictive factor for cardiovascular disease when the effects of other risk factors have been controlled. This study will explore the cardiovascular safety of febuxostat to determine whether the use of febuxostat is associated with a moderate increase in the risk of serious adverse cardiovascular outcomes as compared to allopurinol. Participation will last a maximum of 5 years and will include 15 to 20 visits to the study center.
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Gout is caused by high levels of uric acid in the body, and is associated with a broad range of conditions including heart disease, chronic kidney disease and additional risk factors like obesity and high blood pressure. Hyperuricemia, which is defined as an elevation in serum urate levels, develops into gout when urate crystals form from supersaturated body fluids and settle in joints and other organs. People with gout may also have a higher incidence of other conditions that may be associated with hyperuricemia, gout or both. This is supported by a growing body of research demonstrating that serum urate levels are an independent predictive factor for cardiovascular disease when the effects of other risk factors have been controlled. This study will explore the cardiovascular safety of febuxostat to determine whether the use of febuxostat is associated with a moderate increase in the risk of serious adverse cardiovascular outcomes as compared to allopurinol. Participation will last a maximum of 5 years and will include 15 to 20 visits to the study center.
The eligibility criteria were updated.
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Inclusion Criteria: 1. The subject or the subject's legally acceptable representative signs and dates a written, informed consent form/Health Insurance Portability and Accountability Act (HIPAA) Authorization prior to the initiation of any study procedures. 2. The subject is male ≥50 years of age or female ≥55 years of age and at least 2-years post-menopausal. 3. The subject has a history of major CV or cerebrovascular disease including at least one of the following: - MI. - Hospitalized unstable angina. - Cardiac or cerebrovascular revascularization procedure. - Stroke. - Hospitalized TIA. - Peripheral vascular disease (ankle brachial index ≤0.6, revascularization and/or well-documented history of claudication). - History of diabetes mellitus with evidence of micro- or macrovascular disease (retinopathy, neuropathy, nephropathy, small vessel vascular diseases). 4. The subject has a history or presence of gout defined as having one or more of the American Rheumatism Association criteria for the diagnosis of gout: - A tophus proven to contain urate crystals by chemical or polarized light microscopic means, and/or - Characteristic urate crystals in the joint fluid, and/or - History of at least 6 of the following clinical, laboratory, and x-ray phenomena: - More than 1 attack of acute arthritis. - Maximum inflammation developed within 1 day. - Monoarticular arthritis. - Redness observed over joints. - First metatarsophalangeal joint painful or swollen. - Unilateral first metatarsophalangeal joint attack. - Unilateral tarsal joint attack. - Tophus (proven or suspected). - Hyperuricemia. - Asymmetric swelling within a joint on x-ray. - Subcortical cysts without erosions on x-ray. - Joint fluid culture negative for organisms during attack. 5. The subjects must have either: - a sUA level ≥7.0 mg/dL (≥416 μmol/L) at the Day -7 Visit OR - a sUA level ≥6.0 mg/dL (≥354 μmol/L) at the Day -7 Visit AND inadequately controlled gout (≥1 flare in the 12 months prior to screening and/or the presence of tophi). 6. The subject is capable of understanding and complying with protocol requirements Exclusion Criteria: Subjects who meet any of the following criteria will not qualify for entry into this study: 1. The subject has secondary hyperuricemia (eg, due to myeloproliferative disorder, or organ transplant). 2. The subject has a history of xanthinuria. 3. The subject has received urate-lowering therapy (i.e., febuxostat, allopurinol, probenecid, etc.) or excluded medication during the screening period (beginning with Day -7). 4. The subject has a known hypersensitivity to febuxostat or allopurinol or any components of their formulation. 5. The subject has active peptic ulcer disease. 6. The subject has a history of cancer (other than basal cell carcinoma of the skin) within 5 years prior to the first dose of study medication. 7. The subject had MI or stroke within 60 days prior to the Screening Visit. 8. The subject has ALT and/or AST values greater than 2 times the upper limit of normal (×ULN) during the Screening period. 9. The subject has a significant medical condition and/or conditions that would interfere with the treatment, safety, or compliance with the protocol. 10. The subject has a history of drug abuse (defined as any illicit drug use) or a history of alcohol abuse within 5 years prior to the Screening Visit or the subject consumes >14 alcoholic beverages per week. 11. The subject has received any investigational medicinal product within the 30 days prior to the Screening Visit and throughout the study. 12. The subject's estimated CLcr is <30 mL/min, where CLcr is calculated using the Cockcroft and Gault formula based on ideal body weight (IBW), 13. The subject is an immediate family member, study site employee, or is in a dependant relationship with a study site employee who is involved in conduct of this study (eg, spouse, parent, child, sibling) or may consent under duress. 14. The subject is required to take excluded medications 15. The subject has a known history of infection with hepatitis B, hepatitis C, or human immunodeficiency virus. Inclusion Criteria: - Has a history of major cardiovascular or cerebrovascular disease including at least one of the following: - Myocardial infarction - Hospitalized unstable angina - Cardiac or cerebrovascular revascularization procedure - Stroke - Hospitalized for transient ischemic attack - Peripheral vascular disease - History of diabetes mellitus with evidence of micro- or macrovascular disease - Has a history or presence of gout defined as having one or more of the American Rheumatism Association criteria for the diagnosis of gout: - A tophus proven to contain urate crystals by chemical or polarized light microscopic means, and/or - Characteristic urate crystals in the joint fluid, and/or - History of at least 6 of the following clinical, laboratory, and x-ray phenomena: - More than 1 attack of acute arthritis - Maximum inflammation developed within 1 day - Monoarticular arthritis - Redness observed over joints - First metatarsophalangeal joint painful or swollen - Unilateral first metatarsophalangeal joint attack - Unilateral tarsal joint attack - Tophus (proven or suspected) - Hyperuricemia - Asymmetric swelling within a joint on x-ray - Subcortical cysts without erosions on x-ray - Joint fluid culture negative for organisms during attack - Must have either: - a serum urate level greater than or equal to 7.0 mg/dL at the Day -7 Visit OR - a serum urate level greater than or equal to 6.0 mg/dL at the Day -7 Visit AND inadequately controlled gout Exclusion Criteria: - Has secondary hyperuricemia - Has a history of xanthinuria - Has received urate-lowering or excluded medication during the screening period - Has a known hypersensitivity to febuxostat or allopurinol or any components of their formulation - Has active peptic ulcer disease - Has a history of cancer within 5 years prior to the first dose of study medication - Had a myocardial infarction or stroke within 60 days prior to the Screening Visit - Has alanine aminotransferase and/or aspartate aminotransferase values greater than 2 times the upper limit of normal during the Screening period - Has a history of drug abuse or a history of alcohol abuse within 5 years prior to the Screening Visit or the subject consumes more than14 alcoholic beverages per week - Has received any investigational medicinal product within the 30 days prior to the Screening Visit and throughout the study - Has an estimated creatinine clearance less than 30 mL/min - Is required to take excluded medications - Has a known history of infection with hepatitis B, hepatitis C, or human immunodeficiency virus
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Inclusion Criteria: - Has a history of major cardiovascular or cerebrovascular disease including at least one of the following: - Myocardial infarction - Hospitalized unstable angina - Cardiac or cerebrovascular revascularization procedure - Stroke - Hospitalized for transient ischemic attack - Peripheral vascular disease - History of diabetes mellitus with evidence of micro- or macrovascular disease - Has a history or presence of gout defined as having one or more of the American Rheumatism Association criteria for the diagnosis of gout: - A tophus proven to contain urate crystals by chemical or polarized light microscopic means, and/or - Characteristic urate crystals in the joint fluid, and/or - History of at least 6 of the following clinical, laboratory, and x-ray phenomena: - More than 1 attack of acute arthritis - Maximum inflammation developed within 1 day - Monoarticular arthritis - Redness observed over joints - First metatarsophalangeal joint painful or swollen - Unilateral first metatarsophalangeal joint attack - Unilateral tarsal joint attack - Tophus (proven or suspected) - Hyperuricemia - Asymmetric swelling within a joint on x-ray - Subcortical cysts without erosions on x-ray - Joint fluid culture negative for organisms during attack - Must have either: - a serum urate level greater than or equal to 7.0 mg/dL at the Day -7 Visit OR - a serum urate level greater than or equal to 6.0 mg/dL at the Day -7 Visit AND inadequately controlled gout Exclusion Criteria: - Has secondary hyperuricemia - Has a history of xanthinuria - Has received urate-lowering or excluded medication during the screening period - Has a known hypersensitivity to febuxostat or allopurinol or any components of their formulation - Has active peptic ulcer disease - Has a history of cancer within 5 years prior to the first dose of study medication - Had a myocardial infarction or stroke within 60 days prior to the Screening Visit - Has alanine aminotransferase and/or aspartate aminotransferase values greater than 2 times the upper limit of normal during the Screening period - Has a history of drug abuse or a history of alcohol abuse within 5 years prior to the Screening Visit or the subject consumes more than14 alcoholic beverages per week - Has received any investigational medicinal product within the 30 days prior to the Screening Visit and throughout the study - Has an estimated creatinine clearance less than 30 mL/min - Is required to take excluded medications - Has a known history of infection with hepatitis B, hepatitis C, or human immunodeficiency virus