Inclusion Criteria1. Patients with acute ischemic stroke presenting within 8 hours of onset
2. Patients that present with a large artery occlusion
3. Adults 18 years of age or older.
4. Women of childbearing potential must not be pregnant.
5. National Institutes of Health Stroke Scale (NIHSS) of >5
6. No severe co-morbidities
Exclusion Criteria1. Women that are pregnant
2. History of severe renal disease (e.g. stage 4-5)
3. History of renal transplant