Brain Biomarkers of Response to Treatment for Apraxia of Speech "SPT"

Recruiting

Phase N/A Results N/A

Update History

28 Jul '17
The description was updated.
New
The goals of the current study are to identify grey and white matter regions that are predictive of speech treatment response and measure neural plasticity in response to speech treatment, using state-of-the-art neuroimaging and statistical processing techniques in a group of well-characterized left hemisphere patients meeting strict inclusionary criteria. Specifically, the investigators will use voxel-based lesion symptom mapping to identify lesion sites most predictive of a positive response to speech treatment and advanced diffusion imaging techniques to map changes in the integrity of white matter tracts from pre- to post-treatment.
Old
The goals of the current study are to identify grey and white matter regions that are predictive of speech treatment response and measure neural plasticity in response to speech treatment, using state-of-the-art neuroimaging and statistical processing techniques in a group of well-characterized left hemisphere patients meeting strict inclusionary criteria. Specifically, the investigators will use voxel-based lesion symptom mapping to identify lesion sites most predictive of a positive response to speech treatment and advanced diffusion imaging techniques to map changes in the integrity of white matter tracts from pre- to post-treatment.
The gender criteria for eligibility was updated to "All."
The eligibility criteria were updated.
New
Inclusion Criteria: - Inclusion criteria are age 40-90 - primary English speaker since < age 5 - a history of a single left hemisphere stroke - at least 1 year post-stroke - at least 12 years of education - pre-morbidly right-handed (Edinburgh Handedness Questionnaire) - within normal limits on the Test of Non-Verbal Intelligence Exclusion Criteria: - Exclusion criteria will include a pre-morbid neurologic or psychiatric history - history/current substance abuse disorder - MRI contraindications - other motor speech disorders (e.g., dysarthria) - current or recent (<2 months) speech/language therapy - prior SPT - pre-morbid history of speech/language disorders - significant hearing disabilities (based on a pure-tone audiological screen at 35 dB HL at 500, 1K, and 2K Hz for at least one ear) - aphasia severity resulting in <30th percentile performance on the Porch Index of Communicative Ability-R
Old
Inclusion Criteria: - Inclusion criteria are age 40-90 - primary English speaker since < age 5 - a history of a single left hemisphere stroke - at least 1 year post-stroke - at least 12 years of education - pre-morbidly right-handed (Edinburgh Handedness Questionnaire) - within normal limits on the Test of Non-Verbal Intelligence Exclusion Criteria: - Exclusion criteria will include a pre-morbid neurologic or psychiatric history - history/current substance abuse disorder - MRI contraindications - other motor speech disorders (e.g., dysarthria) - current or recent (<2 months) speech/language therapy - prior SPT - pre-morbid history of speech/language disorders - significant hearing disabilities (based on a pure-tone audiological screen at 35 dB HL at 500, 1K, and 2K Hz for at least one ear) - aphasia severity resulting in <30th percentile performance on the Porch Index of Communicative Ability-R
10 Mar '16
The description was updated.
New
The goals of the current study are to identify grey and white matter regions that are predictive of speech treatment response and measure neural plasticity in response to speech treatment, using state-of-the-art neuroimaging and statistical processing techniques in a group of well-characterized left hemisphere patients meeting strict inclusionary criteria. Specifically, the investigators will use voxel-based lesion symptom mapping to identify lesion sites most predictive of a positive response to speech treatment and advanced diffusion imaging techniques to map changes in the integrity of white matter tracts from pre- to post-treatment.
Old
The goals of the current study are to identify grey and white matter regions that are predictive of speech treatment response and measure neural plasticity in response to speech treatment, using state-of-the-art neuroimaging and statistical processing techniques in a group of well-characterized left hemisphere patients meeting strict inclusionary criteria. Specifically, we will use voxel-based lesion symptom mapping to identify lesion sites most predictive of a positive response to speech treatment and advanced diffusion imaging techniques to map changes in the integrity of white matter tracts from pre- to post-treatment.
8 May '15
The eligibility criteria were updated.
New
Inclusion Criteria: - Inclusion criteria are age 40-90 - primary English speaker since < age 5 - a history of a single left hemisphere stroke - at least 1 year post-stroke - at least 12 years of education - pre-morbidly right-handed (Edinburgh Handedness Questionnaire) - within normal limits on the Test of Non-Verbal Intelligence Exclusion Criteria: - Exclusion criteria will include a pre-morbid neurologic or psychiatric history - history/current substance abuse disorder - MRI contraindications - other motor speech disorders (e.g., dysarthria) - current or recent (<2 months) speech/language therapy - prior SPT - pre-morbid history of speech/language disorders - significant hearing disabilities (based on a pure-tone audiological screen at 35 dB HL at 500, 1K, and 2K Hz for at least one ear) - aphasia severity resulting in <30th percentile performance on the Porch Index of Communicative Ability-R
Old
Inclusion Criteria: - Inclusion criteria are age 40-70 - primary English speaker since < age 5 - a history of a single left hemisphere stroke - at least 1 year post-stroke - at least 12 years of education - pre-morbidly right-handed (Edinburgh Handedness Questionnaire) - within normal limits on the Test of Non-Verbal Intelligence Exclusion Criteria: - Exclusion criteria will include a pre-morbid neurologic or psychiatric history - history/current substance abuse disorder - MRI contraindications - other motor speech disorders (e.g., dysarthria) - current or recent (<2 months) speech/language therapy - prior SPT - pre-morbid history of speech/language disorders - significant hearing disabilities (based on a pure-tone audiological screen at 35 dB HL at 500, 1K, and 2K Hz for at least one ear) - aphasia severity resulting in <30th percentile performance on the Porch Index of Communicative Ability-R
27 Jun '14
A location was updated in Sacramento.
New
The overall status was updated to "Recruiting" at VA Northern California Health Care System, Mather, CA.