Brain Biomarkers of Response to Treatment for Apraxia of Speech "SPT"

Recruiting

Phase N/A Results N/A

Trial Description

The study will use MRI brain imaging to identify brain changes associated in stroke patients after they receive speech-language treatment for their speech difficulties.

Detailed Description

The goals of the current study are to identify grey and white matter regions that are predictive of speech treatment response and measure neural plasticity in response to speech treatment, using state-of-the-art neuroimaging and statistical processing techniques in a group of well-characterized left hemisphere patients meeting strict inclusionary criteria. Specifically, the investigators will use voxel-based lesion symptom mapping to identify lesion sites most predictive of a positive response to speech treatment and advanced diffusion imaging techniques to map changes in the integrity of white matter tracts from pre- to post-treatment.

Conditions

Interventions

  • Speech Production Treatment Behavioral
    Intervention Desc: This treatment employs a response-contingent hierarchy made up of verbal modeling/repetition, graphic cueing, integral stimulation, and articulatory placement instruction.
    ARM 1: Kind: Experimental
    Label: Speech Production Treatment
    Description: This treatment employs a response-contingent hierarchy made up of verbal modeling/repetition, graphic cueing, integral stimulation, and articulatory placement instruction. We chose this treatment for the following reasons: 1) rigor of development demonstrated across multiple studies, 2) large and predictable effects with published, quantified effect sizes, 3) a demonstrated pattern of generalization to untrained items, illustrating experimental control, 4) an established multi-modal stimulation protocol, and 5) use of repeated practice, which is associated with neural plasticity.

Trial Design

  • Masking: Open Label
  • Purpose: Basic Science
  • Intervention: Single Group Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Percent change in naming score for trained and untrained items 8 weeks No
Secondary Change in fractional anisotropy 8 weeks No

Sponsors