Bolus of Saline in Stroke "BOSS"


Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- Age ≥ 18 years
- Acute ischemic stroke in the territory of the anterior, middle, or posterior cerebral artery territory on either side of the brain
- Study intervention can be initiated within 96 hours of symptom onset
- Willingness and ability to sign informed consent by patient or legally acceptable surrogate decision-maker

Exclusion Criteria

- Infarct limited to the brainstem and/or cerebellum with no involvement of the cerebral hemispheres
- Bi-hemispheric infarction or acute infarct in the contra-lateral hemisphere within the past 30 days
- Symptoms of active congestive heart failure (dyspnea, orthopnea, increased oxygen requirement)
- Exacerbation of congestive heart failure, requiring hospitalization, within the past 30 days or severe systolic dysfunction with a known ejection fraction <20%
- End stage renal disease requiring hemodialysis or a creatinine clearance <20 ml/min/1.73 m2
- Hemicraniectomy or other skull defect that would interfere with monitoring
- Pregnant women are excluded. Women of child-bearing age must have a negative pregnancy test prior to enrollment
- Participation in another clinical trial
- Any other illness or condition that the investigator feels would pose a hazard to the subject from participation in the study