Blood Pressure Variability and the Prognosis of Ischemic Stroke With Intracranial Artery Stenosis

Recruiting

Phase N/A Results N/A

Trial Description

Correlation study about Blood Pressure Variability and the prognosis of ischemic stroke with intracranial artery stenosis

Detailed Description

Extracranial atherosclerotic stenosis is the main reason for the European and American white ischemic stroke and transient ischemic attack,while Atherosclerotic intracranial arterial stenosis is an important reason for Asian patients with stroke ,accounting for the 33% to 51% of a etiology ratio.The latest research suggests that varying degrees of blood pressure variability can affect the risk of stroke.This study observe the relationship between blood pressure variability and prognosis of ischemic stroke patients with intracranial arterial stenosis,with cranial magnetic resonance imaging (MRI + DWI),magnetic resonance angiography and Trans-cranial Doppler(TCD) .

Conditions

Interventions

  • Atorvastatin (LipitorĀ®)Drug
    Other Names: Lipitor
    Intervention Desc: Atorvastatin 10 - 40mg / d ( statin therapy)
    ARM 1: Kind: Experimental
    Label: amlodipine
    Description: The amlodipine - based antihypertensive treatment group (you can add a diuretic or other )
    ARM 2: Kind: Experimental
    Label: ACEI / ARB
    Description: ACEI / ARB -based antihypertensive treatment group ( you can add the B - blockers or other)
  • Amlodipine Drug
    Intervention Desc: The amlodipine - based antihypertensive treatment group (you can add a diuretic or other )
    ARM 1: Kind: Experimental
    Label: amlodipine
    Description: The amlodipine - based antihypertensive treatment group (you can add a diuretic or other )
  • ACEI / ARB Drug
    Intervention Desc: ACEI / ARB -based antihypertensive treatment group ( you can add the B - blockers or other)
    ARM 1: Kind: Experimental
    Label: ACEI / ARB
    Description: ACEI / ARB -based antihypertensive treatment group ( you can add the B - blockers or other)
  • Aspirin or Clopidogrel Drug
    Intervention Desc: aspirin 100mg / d or Clopidogrel 75mg / d (anti-platelet agents)
    ARM 1: Kind: Experimental
    Label: amlodipine
    Description: The amlodipine - based antihypertensive treatment group (you can add a diuretic or other )
    ARM 2: Kind: Experimental
    Label: ACEI / ARB
    Description: ACEI / ARB -based antihypertensive treatment group ( you can add the B - blockers or other)

Trial Design

  • Allocation: Randomized
  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Safety/Efficacy Study
  • Intervention: Single Group Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary the incidence of stroke in a follow-up period one year Yes
Secondary blood pressure during the compliance status in a follow-up one year Yes
Secondary patients with blood pressure variability in a follow-up one year Yes
Secondary Changes in intracranial arterial stenosis and stiffness before and after the follow-up one year Yes
Secondary Other vascular events ( acute ischemic heart disease or vascular death ) one year Yes

Sponsors