Blood Pressure Reduction to Limit the Evolution of Vascular Brain Lesions in Elderly Individuals "LEOPOLD"


Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria

- 60 to 88 years old patients;
- Patient with cognitive complaint with MMSE ≥ 20performed within 6 months prior to enrollment (with or without dementia)
- Patient with a socio-educational level ≥ 3
- Presence of hyperintensities of moderate to high grade on the last MRI or old scan (grades C and D on the modified Scheltens scale, grades 2/3 Fazekas).
- Hypertension defined by a Systolic Blood Pressure (SBP) and / or a Diastolic Blood Pressure (DBP) ≥ 140/90 mmHg, treated or not
- Affiliation to a social security system

Exclusion Criteria

- Presence of severe orthostatic hypotension defined as a decrease of 30 mmHg in SBP standing within 3 minutes
- Contraindication to MRI (presence of ferromagnetic foreign body (especially some intracranial clips, some heart valves, intraocular foreign bodies, metal prosthesis), subject carrying pacemaker, claustrophobic participants)
- Severe diseases associated with a life expectancy of less than 3 months;
- Major physical impairments that can interfere with the feasibility of the tests (sight, hearing ...)
- Presence of another dementia different than Alzheimer's disease vascular dementia or mixed dementia,
- Persons under guardianship;
- Secondary hypertension: renovascular hypertension, primary aldosteronism, pheochromocytoma ...;
- Patient already receiving 4 or more antihypertensive drugs at maximum dosage
- Patient participating in another clinical research study on drug requiring exclusion period
- severe renal impairment