Blood Pressure in Acute Stroke Collaboration "BASC"


Phase N/A Results

Trial Description

To generate a systematic review of the effects of antihypertensives on acute stroke outcome.


  • Antihypertensives Drug
    Intervention Desc: This category includes all BP lowering drugs in stroke prevention trials

Trial Design

A meta-analysis of data collected in many randomized controlled trials, divided into three parts. Phase I: A small-scale review concerning the efficacy of oral calcium-channel blockers. Phase II: An analysis of grouped data from trials investigating any vasoactive drug used to treat acute stroke. Phase III: An analysis of individual patient data collected in phases I and II.

Patient Involvement

This is a review of data collected in other trials. Researchers gather their data from the CDSR, CCTR, MEDLINE, EMBASE, BIDS ISI, existing review articles, and correspondence with stroke researchers and pharmaceutical companies Patients are not obligated to do anything beyond what is required by their trial.


Type Measure Time Frame Safety Issue
Primary Changes in blood pressure, heart rate, 1-month mortality rate


South Thames & Trent Regional Health Authority National Health Service Research and Development Executives; The Stroke Association. The study is being performed under the auspices of the Cochrane Collaboration Stroke Group and is published in the Cochrane Library.