This prospective observational study will investigate the frequency of new onset atrial fibrillation (AF) and of further cardiac arrhythmias as well as of (clinically silent) cerebral lesions in endurance runners before, during and after the BMW-Berlin Marathon 2011.
Up to 120 experienced marathon runners will participate in the "Berlin Beat of Running Study" and will wear a transportable electrocardiogram (ECG) recorder at least 24 hours before, during and 24 hours after the BMW-Berlin Marathon. All participants will undergo brain MRI examinations to detect cerebral lesions within days before and after the marathon race, respectively. Moreover, serial blood samples will be taken a few days before, immediately after as well as a few days after the BMW-Berlin Marathon.
- Observation: Cohort
- Perspective: Prospective
- Sampling: Probability Sample
Experienced marathon runners
|Type||Measure||Time Frame||Safety Issue|
|Primary||Rate of cardiac arrhythmias in marathon runners detected by mobile ECG-recording||Up to 48 hours after the marathon race.||No|
|Secondary||Rate of (clinically silent) cerebral lesions detected by 3 Tesla brain MRI.||3 days||No|
Biospecimen Retention:Samples Without DNA - Whole blood samples
- Charite University, Berlin, Germany Lead
- Center for Stroke Research Berlin, Germany
- SCC-Events GmbH Berlin, Germany
- Department of Neurology, Charite University, Berlin, Germany
- Medical Institute BMW-Berlin Marathon, Berlin, Germany
- Department of Cardiology, Campus Virchow, Charite University, Berlin, Germany