Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke "ASPIS"


Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria

- Symptomatic ischemic stroke with clinical syndrome of stroke and a corresponding ischemic lesion.
- MRI or CT results compatible with clinical diagnosis of acute ischemic stroke
- NIH Stroke Scale Score on admission 1 to 14, both inclusive
- Modified Rankin Scale before stroke 0 to 2, inclusive
- Randomization within 3 months after stroke onset (goal: 80% within 3 weeks)
- Sufficient communication possible
- Informed consent given by the patient and/or the patient's legally acceptable representative

Exclusion Criteria

- Substantial cognitive decline (Mini Mental State Examination (MMSE) score > 24) or pre-existing dementia or Parkinson disease
- Persistent disturbed level of consciousness
- Persistent aphasia
- Pre-existing significant psychiatric diseases (i.e. Schizophrenia, Major Depression, Bipolar Disorders, all according to DSMIV); Patients with minor Depression (DSM IV) can be included
- Severe sensory impairment making neuropsychological testing impossible
- Severe comorbidity (e.g. unstable or severe cardiovascular or pulmonal disease, neoplasm, severe liver or renal insufficiency and symptomatic stenosis of the ipsilateral carotid artery, cancer…)
- Unreliability for follow up
- Unwillingness or inability to participate or to sign the informed consent